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| Packungsgröße | SKU | Verfügbarkeit | Preis |
|---|---|---|---|
| 200 mg | Voraussichtlich HEUTE zu versendenvonSchnelldorf | 410,00 € |
Über diesen Artikel
Empirische Formel (Hill-System):
C18H14Cl4N2O · HNO3
CAS-Nummer:
Molekulargewicht:
479.14
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
MDL number:
Technischer Dienst
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Unterstützung erhaltengrade
pharmaceutical primary standard
API family
miconazole
manufacturer/tradename
USP
application(s)
pharmaceutical (small molecule)
format
neat
SMILES string
ClC1=CC(Cl)=CC=C1C(OCC2=CC=C(Cl)C=C2Cl)CN3C=CN=C3.[O-][N+](O)=O
InChI
1S/C18H14Cl4N2O.HNO3/c19-13-2-1-12(16(21)7-13)10-25-18(9-24-6-5-23-11-24)15-4-3-14(20)8-17(15)22;2-1(3)4/h1-8,11,18H,9-10H2;(H,2,3,4)
InChI key
MCCACAIVAXEFAL-UHFFFAOYSA-N
General description
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.
Application
Miconazole nitrate USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
- Miconazole Nitrate Cream
- Miconazole Nitrate Topical Powder
- Miconazole Nitrate Vaginal Suppositories
Biochem/physiol Actions
Antifungales Azol. Wirkungsweise: inhibiert Cytochrom P450-abhängige 14α-Demethylase, die für die Ergosterin-Biosynthese wichtig ist. Die kumulierten 14α-methylierten Sterole ändern die Membranstruktur sensitiver Pilze, was eine geänderte Permeabilität der Zellmembran zur Folge hat. Es inhibiert auch Peroxidasen, wodurch Peroxide in der Zelle angereichert werden.
Miconazol interagiert mit 14-α-Demethylase, einem Cytochrom-P-450-Enzym, das für die Ergosterin-Biosynthese notwendig ist. Die Hemmung von Ergosterol führt zu einer erhöhten zellulären Permeabilität, was zum Leckverlust zellulärer Inhalte führt. Miconazol kann auch endogene Atmung inhibieren, mit Phospholipiden der Zellmembran interagieren, die Transformation von Hefen zu Myzel Formen hemmen, die Purin-Aufnahme hemmen und in die Triglycerid und Phospholipidbiosynthese eingreifen.
Analysis Note
These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.
Other Notes
Sales restrictions may apply.
1 of 1
Dieser Artikel | |||
|---|---|---|---|
| grade pharmaceutical primary standard | grade pharmaceutical primary standard | grade pharmaceutical primary standard | grade certified reference material, pharmaceutical secondary standard |
| manufacturer/tradename USP | manufacturer/tradename EDQM | manufacturer/tradename BP | manufacturer/tradename - |
| application(s) pharmaceutical (small molecule) | application(s) pharmaceutical (small molecule) | application(s) pharmaceutical | application(s) pharmaceutical |
| format neat | format neat | format neat | format - |
| API family miconazole | API family miconazole | API family miconazole | API family - |
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signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Skin Sens. 1
Lagerklasse
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
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Global Trade Item Number
| SKU | GTIN |
|---|---|
| 1443500-200MG | 04061838735577 |