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USP

Amilorid -hydrochlorid

United States Pharmacopeia (USP) Reference Standard

Synonym(e):

Amilorid -hydrochlorid Dihydrat, N-Amidino-3,5-diamino-6-chlorpyrazincarboxamid -hydrochlorid Dihydrat

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500 MG
389,00 €

389,00 €

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500 MG
389,00 €

About This Item

Empirische Formel (Hill-System):
C6H8ClN7O · HCl · 2H2O
CAS-Nummer:
17440-83-4
Molekulargewicht:
302.12
MDL-Nummer:
MFCD11046655
UNSPSC-Code:
41116107
NACRES:
NA.24

389,00 €

Versandbereit am04. April 2025Details

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Qualität

pharmaceutical primary standard

API-Familie

amiloride

Hersteller/Markenname

USP

Anwendung(en)

pharmaceutical (small molecule)

Format

neat

SMILES String

Clc1nc(c(nc1N)N)C(=O)N\C(=N\[H])\N.Cl.O.O

InChI

1S/C6H8ClN7O.ClH.2H2O/c7-2-4(9)13-3(8)1(12-2)5(15)14-6(10)11;;;/h(H4,8,9,13)(H4,10,11,14,15);1H;2*1H2

InChIKey

LTKVFMLMEYCWMK-UHFFFAOYSA-N

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Allgemeine Beschreibung

Amiloride hydrochloride is a photosensitive yellow powder used as a mild diuretic drug.[1]

Anwendung

Amiloride hydrochloride USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
  • Amiloride Hydrochloride and Hydrochlorothiazide Tablets
  • Amiloride Hydrochloride Tablets

Hinweis zur Analyse

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Sonstige Hinweise

Sales restrictions may apply.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

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Analysenzertifikate (COA)

Lot/Batch Number

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Matthias Schoenberger et al.
Expert opinion on therapeutic patents, 23(10), 1383-1389 (2013-08-21)
Novel molecular platforms for epithelial sodium channel (ENaC) modulators are claimed in the following six patents: WO2012035158(A1); WO2009074575(A2); WO2011028740(A1); WO2009150137(A2); WO2011079087(A1); WO2008135557(A1). These ENaC inhibitors may be used in blocking transepithelial sodium and consequently water absorption across airway epithelia. This
Hector Rasgado-Flores et al.
American journal of physiology. Cell physiology, 305(11), C1114-C1122 (2013-08-30)
Hypertonic saline (HS) inhalation therapy benefits cystic fibrosis (CF) patients [Donaldson SH, Bennet WD, Zeman KL, Knowles MR, Tarran R, Boucher RC. N Engl J Med 354: 241-250, 2006; Elkins MR, Robinson M, Rose BR, Harbour C, Moriarty CP, Marks
Mónica C F Ferraro et al.
Journal of pharmaceutical and biomedical analysis, 30(4), 1121-1131 (2002-11-01)
The use of multivariate spectrophotometric calibration for the simultaneous analysis of synthetic samples and commercial tablet preparations containing hydrochlorothiazide (HCT) and amiloride hydrochloride (AMH) is reported. Partial least squares (PLS-1) analysis of electronic absorption spectral data allowed the rapid and
Anne P Sinke et al.
American journal of physiology. Renal physiology, 306(5), F525-F533 (2013-12-20)
Lithium is the most common cause of nephrogenic diabetes insipidus (Li-NDI). Hydrochlorothiazide (HCTZ) combined with amiloride is the mainstay treatment in Li-NDI. The paradoxical antidiuretic action of HCTZ in Li-NDI is generally attributed to increased sodium and water uptake in
Shujie Shi et al.
American journal of physiology. Renal physiology, 305(11), F1585-F1592 (2013-10-11)
The epithelial sodium channel (ENaC) is comprised of three homologous subunits. Channels composed solely of α- and β-subunits (αβ-channels) exhibit a very high open probability (Po) and reduced sensitivity to amiloride, in contrast to channels composed of α- and γ-subunits
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