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T8024

Sigma-Aldrich

Tetrodotoxin

≥98% (HPLC), powder

Synonym(e):

Fugu poison, TTX

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About This Item

Empirische Formel (Hill-System):
C11H17N3O8
CAS-Nummer:
4368-28-9
Molekulargewicht:
319.27
Beilstein:
49176
EG-Nummer:
224-458-8
MDL-Nummer:
MFCD00213719
UNSPSC-Code:
12352200
PubChem Substanz-ID:
24900493

Assay

≥98% (HPLC)

Form

powder

Farbe

white

Löslichkeit

dilute citrate or acetate buffer: 1 mg/mL (dissolve at pH 4-5. Aqueous solutions, pH 4-5, are stable if stored frozen.)
strong acid or alkaline solutions: unstable (destroyed by boiling at pH 2.)

Lagertemp.

2-8°C

SMILES String

[H][C@]12OC3(O)OC(C4[C@@H](O)NC(=N)NC4([C@@H]1O)[C@@H]3O)[C@@]2(O)CO

InChI

1S/C11H17N3O8/c12-8-13-6(17)2-4-9(19,1-15)5-3(16)10(2,14-8)7(18)11(20,21-4)22-5/h2-7,15-20H,1H2,(H3,12,13,14)/t2?,3-,4?,5+,6-,7+,9+,10?,11?/m1/s1

InChIKey

CFMYXEVWODSLAX-IXUBDLNJSA-N

Angaben zum Gen

rat ... Scnn1g(24768)

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Anwendung

Tetrodotoxin has been used as standard during HPLC-based analysis of biotoxins from P. punctata tentacles whole crude extract (PHY-N). Tetrodotoxin has also been used to study its effects on low-threshold transient (LTT) Ca2+ currents in rat hippocampal interneurons.

Biochem./physiol. Wirkung

Reversible, selective blocker of Na+ channels; blocks propagation of impulses in excitable membranes. Used to characterize sodium channels in excitable membranes and to study the role of sodium channels in normal physiology and disease.

Angaben zur Herstellung

Tetrodotoxin is soluble in dilute citrate or acetate buffer at 1 mg/ml (pH 4-5). Aqueous solutions are stable at pH 4-5 if stored frozen. However, tetrodotoxin is unstable in strong acid or alkaline solutions and is destroyed by boiling at pH2.

Piktogramme

Skull and crossbones
GHS06

Signalwort

Danger

H-Sätze

H300

Gefahreneinstufungen

Acute Tox. 1 Oral

Lagerklassenschlüssel

6.1B - Non-combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Persönliche Schutzausrüstung

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Analysenzertifikate (COA)

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Sigma-Aldrich

N9407

Neuropeptide Y Fragment 3-36 human, rat

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