D134

3,7-Dimethyl-1-propargylxanthine

≥98% (HPLC), powder

• Synonym(e): 3,7-Dimethyl-1-(2-propynyl)xanthine, DMPX
• Empirische Formel (Hill-System): C₁₀H₁₀N₄O₂
• CAS-Nummer: 14114-46-6
• Molekulargewicht: 218.21
• MDL-Nummer: MFCD00078576
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24277754
• NACRES: NA.77

Eigenschaften

• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to beige
• Löslichkeit: DMSO: 15 mg/mL, clear
• SMILES String: CN1C(=O)N(CC#C)C(=O)c2c1ncn2C
• InChI: 1S/C10H10N4O2/c1-4-5-14-9(15)7-8(11-6-12(7)2)13(3)10(14)16/h1,6H,5H2,2-3H3
• InChIKey: IORPOFJLSIHJOG-UHFFFAOYSA-N
• Angaben zum Gen: human ... ADORA2A(135) , ADORA2B(136) ; rat ... Adora1(29290) , Adora2a(25369)

Beschreibung

Anwendung

3,7-Dimethyl-1-propargylxanthine (DMPX) has been used as an A₂ -adenosine receptor (AR) antagonist:

• to study its effects on potential modulation of motor output elicited by epidural spinal stimulation (ESS)
• to study the role of A_2a receptor in elevating cyclic adenosine monophosphate (cAMP) levels
• to study its effects on the cell viability of human gastric cancer cell line

Biochem./physiol. Wirkung

3,7-Dimethyl-1-propargylxanthine (DMPX) is a caffeine analog and A₂-selective adenosine receptor (AR) antagonist.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H315,H319,H335
• P-Sätze: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Gefahreneinstufungen: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Zielorgane: Respiratory system
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Gloves