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B150

Sigma-Aldrich

BQ-123

≥99%, sodium salt, lyophilized powder

Synonym(e):

BQ123, Cyclo(D-Trp-D-Asp-Pro-D-Val-Leu)

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200 μG
168,00 €
1 MG
225,50 €

168,00 €

Versandbereit am31. März 2025Details

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200 μG
168,00 €
1 MG
225,50 €

About This Item

Empirische Formel (Hill-System):
C31H41N6O7 Na
CAS-Nummer:
136553-81-6
Molekulargewicht:
632.68
MDL-Nummer:
MFCD00133204
UNSPSC-Code:
12352204
PubChem Substanz-ID:
24891595
NACRES:
NA.32

168,00 €

Versandbereit am31. März 2025Details

Qualitätsniveau

200

Assay

≥99%

Form

lyophilized powder

Lagertemp.

−20°C

SMILES String

[H][C@@]12CCCN1C(=O)[C@@H](CC(O)=O)NC(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](NC2=O)C(C)C

InChI

1S/C31H42N6O7/c1-16(2)12-21-27(40)33-22(13-18-15-32-20-9-6-5-8-19(18)20)28(41)35-23(14-25(38)39)31(44)37-11-7-10-24(37)29(42)36-26(17(3)4)30(43)34-21/h5-6,8-9,15-17,21-24,26,32H,7,10-14H2,1-4H3,(H,33,40)(H,34,43)(H,35,41)(H,36,42)(H,38,39)/t21-,22+,23+,24-,26+/m0/s1

InChIKey

VYCMAAOURFJIHD-PJNXIOHISA-N

Angaben zum Gen

human ... EDNRA(1909) , EDNRB(1910)
rat ... Ednra(24326) , Ednrb(50672)

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Amino Acid Sequence

cyclo-Asp-Pro-Val-Leu-Trp

Anwendung

BQ-123 has been used as a selective endothelin-A receptor antagonist to study its effects on tumor necrosis factor α (TNFα)-induced human airway smooth muscle cells (HASMCs) proliferation.[1] It is also used as endothelin-A receptor antagonist to study its effects on TNFα-induced granulocyte–macrophage colony-stimulating factor (GM-CSF) expression.[2]

Biochem./physiol. Wirkung

BQ-123 is an endothelin(Et) receptor antagonist and is exquisite for endothelin A (ETA) receptor.[3] It is a cyclic pentapeptide.[4]
Selective ETA endothelin receptor antagonist.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number
0000142404
0000253738
0000253737
089M4069V
089M4068V

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F Cosentino et al.
Journal of cardiovascular pharmacology, 22 Suppl 8, S332-S335 (1993-01-01)
The present study was designed to determine whether an endothelinA (ETA)-receptor antagonist BQ-123 (cyclo[Dtrp, Dasp, pro-D-Val-Leu]) or an ET-converting enzyme inhibitor phosphoramidon may prevent development of cerebral vasospasm after subarachnoid hemorrhage (SAH). A "double hemorrhage" canine model of the disease
T D Warner et al.
British journal of pharmacology, 112(1), 207-213 (1994-05-01)
1. Endothelin-1 binds almost irreversibly to its receptors and causes prolonged vasoconstrictions. Here we have studied the reversal of established responses to ET-1 in vivo and in vitro by BQ-123, an ETA receptor-selective antagonist, and/or PD 145065, an ETA/ETB receptor
J Knobloch et al.
Thorax, 64(12), 1044-1052 (2009-10-24)
There is an urgent need to inhibit endothelin-1 (ET-1) induced chronic inflammatory processes in early stages of lung diseases in order to prevent untreatable irreversible stages often accompanied by lung fibrosis and pulmonary hypertension. Nothing is known about the airway
M Clozel et al.
Life sciences, 52(9), 825-834 (1993-01-01)
The aim of this study was to evaluate the role of endothelin and endothelin ETA receptor in the early cerebral vasoconstriction following subarachnoid hemorrhage (SAH) in the rat. SAH induced by injection of autologous blood in the cisterna magna reduced
Sarah Pisarcik et al.
American journal of physiology. Lung cellular and molecular physiology, 304(8), L549-L561 (2013-02-19)
Numerous cellular responses to hypoxia are mediated by the transcription factor hypoxia-inducible factor-1 (HIF-1). HIF-1 plays a central role in the pathogenesis of hypoxic pulmonary hypertension. Under certain conditions, HIF-1 may utilize feedforward mechanisms to amplify its activity. Since hypoxia
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Fragen

1-4 von 4 Fragen  

  1. Is Product B150 the free acid form of BQ-123, or is it a salt?

    1 Antwort

    1. Product No. B150 is BQ123 sodium salt.

      Hilfreich?

  2. How should Product B150, BQ-123, be dissolved?

    1 Antwort

    1. This product is soluble in water (0.25mg/ml), yielding a clear colorless solution.

      Hilfreich?

  3. What is the Department of Transportation shipping information for this product?

    1 Antwort

    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

      Hilfreich?

  4. What is the solution stability for Product B150, BQ-123?

    1 Antwort

    1. We do not perform any solution stability studies on Product B150, BQ-123. The following reference indicates that the product is stable in solution for 24 hours but no temperature was mentioned.  Cardillo, C. et al., Hypertension, 33, 753-758 (1999).  The following abstract indicates that BQ-123 was used in an osmotic pump for a 2 week treatment.  Bonvollet, S. et al., A.J.P. - Heart, 266 (4), H1327-H1331 (1994).

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