Direkt zum Inhalt
Merck

Fortfahren mit

A5486

Azoxymethan

13.4 M, ≥98%

Synonym(e):

AOM

Anmelden zur Ansicht der Organisations- und Vertragspreise.

Größe auswählen

Ansicht ändern
PackungsgrößeSKUVerfügbarkeitPreis
25 mg
Warenkorb auf Verfügbarkeit prüfen
471,00 €
100 mg

Voraussichtlich HEUTE zu versendenvonSchnelldorf

1.420,00 €

Über diesen Artikel

Lineare Formel:
CH3N=N(→O)CH3
CAS-Nummer:
Molekulargewicht:
74.08
NACRES:
NA.25
PubChem Substance ID:
UNSPSC Code:
12352124
MDL number:
Assay:
≥98%
Form:
liquid
Storage condition:
(Keep container tightly closed in a dry and well-ventilated place.)

471,00 €


Warenkorb auf Verfügbarkeit prüfen

Großbestellung anfragen
Technischer Dienst
Benötigen Sie Hilfe? Unser Team von erfahrenen Wissenschaftlern ist für Sie da.
Unterstützung erhalten


Quality Segment

assay

≥98%

form

liquid

composition

methylene chloride, ≤1%

storage condition

(Keep container tightly closed in a dry and well-ventilated place.)

concentration

13.4 M

color

colorless

bp

97-99 °C (lit.)

density

0.991 g/mL at 25 °C (lit.)

application(s)

genomic analysis

storage temp.

−20°C

SMILES string

C\N=[N+](/C)[O-]

InChI

1S/C2H6N2O/c1-3-4(2)5/h1-2H3/b4-3+

InChI key

DGAKHGXRMXWHBX-ONEGZZNKSA-N

General description

Azoxymethan (AOM) ist eine hochwirksame Laborchemikalie zur Untersuchung der Entstehung, Progression und Prävention von Krebs, insbesondere im Kolon. Es wirkt sowohl als Karzinogen, das die Tumorbildung auslöst, als auch als Genmutationswirkstoff, der spezifische Veränderungen der DNA verursacht.

Application

Azoxymethan (AOM) ist ein Genmutationsmittel und kann zusammen mit Natriumdextransulfat (DSS) zur Erstellung von Krebsmodellen in Labortieren, die zur Untersuchung von Mechanismen der Krebsentwicklung und chemischen Vorbeugung dienen, verwendet werden.

Biochem/physiol Actions

Karzinogen, das O6-Methylguanin-Addukte in der DNA induziert, was zu G→A-Übergängen führt. Induziert Tumorgenese im Darm von Labortieren und wird zur Untersuchung des Mechanismus der Krebsprogredienz und Chemoprävention verwendet.

Features and Benefits

Vielseitig und anpassbar an eine Vielzahl von Labor- und Forschungsanwendungen

Other Notes

Es ist äußerst wichtig, beim experimentellen Verfahren die genaue Azoxymethandosierung zu bestimmen, um einem frühzeitigen Tod der Labortiere vorzubeugen.
Füllen Sie bitte dieses Formular aus, um weitere Informationen zu unserem Sortiment an Biochemikalien zu erhalten.

Ähnliche Artikel vergleichen

Vollständigen Vergleich anzeigen

Unterschiede anzeigen

1 of 1

Dieser Artikel
118502344906409081
form

liquid

form

liquid

form

liquid

form

viscous liquid

assay

≥98%

assay

≥95% (HPLC)

assay

≥95% (HPLC)

assay

-

Quality Level

200

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

-

storage condition

(Keep container tightly closed in a dry and well-ventilated place.)

storage condition

OK to freeze, desiccated (hygroscopic), protect from light

storage condition

OK to freeze, protect from light

storage condition

-

color

colorless

color

-

color

-

color

-


signalword

Danger

Hazard Classifications

Acute Tox. 2 Oral - Carc. 1B - Eye Irrit. 2 - Flam. Liq. 3 - Skin Irrit. 2

Lagerklasse

3 - Flammable liquids

wgk

WGK 3

flash_point_f

75.2 °F

flash_point_c

24 °C


Zulassungslistungen

Zulassungslistungen werden hauptsächlich für chemische Produkte erstellt. Für nicht-chemische Produkte können hier nur begrenzte Angaben gemacht werden. Kein Eintrag bedeutet, dass keine der Komponenten gelistet ist. Es liegt in der Verantwortung des Benutzers, die sichere und legale Verwendung des Produkts zu gewährleisten.

75-09-2

CAS No.


Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number

Die passende Version wird nicht angezeigt?

Wenn Sie eine bestimmte Version benötigen, können Sie anhand der Lot- oder Chargennummer nach einem spezifischen Zertifikat suchen.

Besitzen Sie dieses Produkt bereits?

In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

Die Dokumentenbibliothek aufrufen


Verwandter Inhalt

Find high-purity biochemicals for every workflow. Explore BioUltra, Molecular Biology, BioReagent, and reagent-grade materials qualified for performance.






Global Trade Item Number

SKUGTIN
A5486-100MG04061837839597
A5486-25MG04061837839603

Fragen

1-10 von 11 Fragen  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 Antwort
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

      Hilfreich?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 Antwort
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Hilfreich?

  3. What is the solubility of product A5486 (Azoxymethane, CAS number 25843-45-2)?

    1 Antwort
    1. The solubility of Azoxymethane (CAS 25843-45-2) is as follows:

      • Water solubility: approximately 100mg/mL
      • DMSO solubility: approximately 100mg/mL
      • Ethanol (95%) solubility: approximately 100mg/mL
      • Acetone solubility: approximately 100mg/mL

      Hilfreich?

  4. Could I know the concentration (mg/ml) and volume of Azoxymethane 13.4M in A5486-100MG?

    1 Antwort
    1. This product is considered to be a pure/neat chemical (not in solution), with a purity specification of at least 98%. The g/mL would be the density, of 0.991 g/mL. The volume of 100 mg is going to be approximately 100.9 microliters, but products are often over-filled by a few percent, so it would be recommended to still weigh the material during or prior to use.

      Hilfreich?

  5. Is Axozymethane volatile?

    1 Antwort
    1. Yes, this compound is considered to be a volatile substance. Please review the entire Safety Data Sheet before handling it.

      Hilfreich?

  6. What are the approximate volumes for the of 25 mg and 100 mg, package sizes of Product No. A5486, Azoxymethane?

    1 Antwort
    1. Using the literature value for density of approximately 0.991 g/mL (at 25 °C), the approximate volumes are 25 μL for the 25 mg package size and 100 μl for the 100 mg package size.

      Hilfreich?

  7. How should stock solutions of Azoxymethane be stored, and for how long can they be kept?

    1 Antwort
    1. No solution stability studies have been performed by Sigma-Aldrich. Because the solution stability is unknown, solutions should be prepared fresh for use.

      Hilfreich?

  8. What is the Department of Transportation shipping information for this product?

    1 Antwort
    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

      Hilfreich?

  9. How does the storage temperature relate to shipping conditions?

    1 Antwort
    1. The storage conditions that a Sigma-Aldrich catalog and label recommend for products are deliberately conservative. For many products, long-term storage at low temperatures will increase the time during which they are expected to remain in specification and therefore are labeled accordingly. Where short-term storage, shipping time frame, or exposure to conditions other than those recommended for long-term storage will not affect product quality, Sigma-Aldrich will ship at ambient temperature. The products sensitive to short-term exposure to conditions other than their recommended long-term storage are shipped on wet or dry ice. Ambient temperature shipping helps to control shipping costs for our customers. At any time, our customers can request wet- or dry-ice shipment, but the special handling is at customer expense if our product history indicates that the product is stable for regular shipment.

      Hilfreich?

  10. How does azoxymethane act to cause cancers?

    1 Antwort
    1. Azoxymethane is a methylating agent which forms 6-O-methylguanine in DNA.  Unless this methylated base is repaired by cellular enzymes, it results in a base mismatch that subsequently causes tumors in the tissue.

      Hilfreich?

1-10 von 11 Fragen  

Bewertungen

Kein Beurteilungswert

Aktive Filter