A265

ARL 67156 trisodium salt hydrate

≥98% (HPLC), solid, ecto-ATPase inhibitor

• Synonym(e): 6-N,N-Diethyl-β-γ-dibromomethylene-D-adenosine-5′-triphosphate trisodium salt hydrate, FPL 67156
• Empirische Formel (Hill-System): C₁₅H₂₁Br₂N₅Na₃O₁₂P₃ · xH₂O
• CAS-Nummer: 160928-38-1
• Molekulargewicht: 785.05 (anhydrous basis)
• MDL-Nummer: MFCD12910436
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24278252
• NACRES: NA.77

Eigenschaften

• product name: ARL 67156 trisodium salt hydrate, ≥98% (HPLC), solid
• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: solid
• Farbe: white to off-white
• Löslichkeit: H₂O: >20 mg/mL; DMSO: insoluble
• Lagertemp.: −20°C
• SMILES String: O.[Na+].[Na+].[Na+].CCN(CC)c1ncnc2n(cnc12)[C@@H]3O[C@H](COP(O)(=O)OP([O-])(=O)C(Br)(Br)P([O-])([O-])=O)[C@@H](O)[C@H]3O
• InChI: 1S/C15H24Br2N5O12P3.3Na.H2O/c1-3-21(4-2)12-9-13(19-6-18-12)22(7-20-9)14-11(24)10(23)8(33-14)5-32-37(30,31)34-36(28,29)15(16,17)35(25,26)27;;;;/h6-8,10-11,14,23-24H,3-5H2,1-2H3,(H,28,29)(H,30,31)(H2,25,26,27);;;;1H2/q;3*+1;/p-3/t8-,10-,11-,14-;;;;/m1..../s1
• InChIKey: UWMONIJVKGTUGE-OPKBHZIBSA-K
• Angaben zum Gen: human ... ENTPD2(954)

Beschreibung

Allgemeine Beschreibung

ARL 67156, a nucleotide/ATP analog is a competitive inhibitor of CD39. This ecto-ATPase inhibitor is presumed to be metabolically stable in biological studies due to its β, γ-dibromomethylene bridge.

ARL-67156 preferentially inhibits the degradation of ADP compared to the degradation of ATP in the murine colon. It is commonly employed to inhibit ATP hydrolysis in tissue preparations.

Anwendung

ARL 67156 trisodium salt hydrate has been used:

• to prevent ATP degradation during cerebrospinal fluid extraction
• as an ATPase inhibitor in ATP quantification assay for preventing ATP degradation in cytoplasm and mitochondrion
• as an ecto-ATPase inhibitor to treat cancer cells for ATP release assay

Biochem./physiol. Wirkung

ecto-ATPase inhibitor; prevents metabolism of P₂ purinoceptor agonists.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3