E8399

Eotaxin-3 human

>97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

• Synonym(e): CCL26, SCYA26
• MDL-Nummer: MFCD01867165
• UNSPSC-Code: 12352202
• NACRES: NA.32

Eigenschaften

• Biologische Quelle: human
• Qualitätsniveau: 200
• Rekombinant: expressed in E. coli
• Assay: >97% (SDS-PAGE)
• Form: lyophilized powder
• Wirksamkeit: 0.25-1.0 mg
• Mol-Gew.: ~8.2 kDa
• Verpackung: pkg of 25 μg
• Lagerbedingungen: avoid repeated freeze/thaw cycles
• Methode(n): cell culture | mammalian: suitable
• Verunreinigungen: endotoxin, tested
• UniProt-Hinterlegungsnummer: Q9Y258
• Lagertemp.: −20°C
• Angaben zum Gen: human ... CCL26(10344)

Beschreibung

Allgemeine Beschreibung

Eotaxin-3, also known as CCL26 or SCYA26, is a human CC chemokine and a functional ligand for CC chemokine receptor 3.[1] This gene is localized to human chromosome 7q11.2, which codes for a protein of 71 amino acids.[2] It belongs to the small inducible cytokine subfamily A [3], which also includes eotaxin and eotaxin-2.[4]

Biochem./physiol. Wirkung

Also known as CCL26 or SCYA26; a human CC chemokine and a functional ligand for CC chemokine receptor 3; mature recombinant human eotaxin-3 demonstrates chemotactic activity for eosinophils.

Eotaxin-3 is a potent attractant of eosinophils, and might be responsible for the accumulation of eosinophils in atopic diseases.[2] As it is involved in the recruitment of eosinophils in inflammatory diseases, it, along with its receptor, might have potential as therapeutic target in inflammatory disorders, such as asthma.[1] Demethylation results in increased expression of this gene, which in turn influences allergic reactions.[5] This gene is overexpressed in bullous pemphigoid (BP), which results in the accumulation of eosinophils in skin lesions, thus, contributing to the pathogenesis of BP.[4] Its expression is also elevated in the active lesions of patients with ulcerative colitis (UC) and Crohn′s disease (CD). Thus, it might play a role in the pathogenesis of UC, where its major source is colonic myofibroblasts.[6]

Eotaxin-3, also known as CCL26 or SCYA26, is a human CC chemokine and a functional ligand for CC chemokine receptor 3. Mature recombinant human eotaxin-3 has a molecular mass of approximately 8.2 kDa and demonstrates chemotactic activity for eosinophils.

Physikalische Form

Lyophilized from a 0.2 μm filtered solution in 30% acetonitrile and 0.1% trifluoroacetic acid containing 1.25 mg bovine serum albumin.

Hinweis zur Analyse

The biological activity is measured by its ability to induce chemotaxis of rat Y3 cells stably expressing hCCR3.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H319,H332
• P-Sätze: P261 - P264 - P271 - P280 - P304 + P340 + P312 - P305 + P351 + P338
• Gefahreneinstufungen: Acute Tox. 4 Inhalation - Eye Irrit. 2
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 2
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable