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F7876

Folic acid

≥97%

Synonyme(s) :

PteGlu, Pteroyl-L-glutamic acid, Vitamin M

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ConditionnementRéférenceDisponibilitéPrix
1 g
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35,80 $
10 g
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102,00 $
25 g
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202,00 $
100 g
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667,00 $

A propos de cet article

Formule empirique (notation de Hill) :
C19H19N7O6
Numéro CAS:
Poids moléculaire :
441.40
NACRES:
NA.79
PubChem Substance ID:
eCl@ss:
34058014
UNSPSC Code:
12352106
EC Number:
200-419-0
MDL number:
Beilstein/REAXYS Number:
100781

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biological source

synthetic (organic)

Quality Level

assay

≥97%

form

powder

technique(s)

HPLC: suitable

color

faint orange to dark orange-yellow, faint yellow to dark yellow

mp

>285 °C

storage temp.

room temp

SMILES string

NC(N1)=NC(C2=C1N=CC(CNC3=CC=C(C(N[C@@H](CCC(O)=O)C(O)=O)=O)C=C3)=N2)=O

InChI

1S/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s1

InChI key

OVBPIULPVIDEAO-LBPRGKRZSA-N

Application

Folic acid has been used:
  • to induce acute kidney injury in mice
  • as a supplement to cultivate MCF-7 breast cancer cells.
  • to construct folate or TNF-related apoptosis-including ligand (TRAIL)-conjugated nanomicelles

Biochem/physiol Actions

Enzyme cofactor essential for the synthesis, methylation, and repair of DNA. Folic acid supplements may reduce colorectal cancer risk.
Folic acid (FA) and dihydrofolic acid (FAH2) are substrates of dihydrofolate reductase(s) which reduce them to tetrahydrofolate (THF), which in turn supports ‘one carbon′ transfer. Tetrahydrofolates are required for de novo synthesis of purines, thymidylic acid and various amino acids and for post-translational methylation (epigenetics).

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Cet article
F87581286005F8798
Folic acid United States Pharmacopeia (USP) Reference Standard

USP

1286005

Folic acid

technique(s)

HPLC: suitable

technique(s)

cell culture | insect: suitable, cell culture | mammalian: suitable, cell culture | plant: suitable

technique(s)

-

technique(s)

-

assay

≥97%

assay

≥97%

assay

-

assay

97.0-102.0% dry basis

biological source

synthetic (organic)

biological source

synthetic

biological source

-

biological source

synthetic (organic)

form

powder

form

powder

form

-

form

solid

storage temp.

room temp

storage temp.

room temp

storage temp.

-

storage temp.

-

Quality Level

200

Quality Level

300

Quality Level

-

Quality Level

300


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Classe de stockage

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)



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Hassoun M, et al.
Beilstein Journal of Nanotechnology, 8, 1183-1183 (2017)
Fibroblast Growth Factor 23 Expression is increased in Multiple Organs in Mice with Folic Acid-induced Acute Kidney Injury.
Egli-Spichtig D, et al.
Frontiers in Physiology, 9, 1494-1494 (2018)
Romain Froquet et al.
Nature protocols, 4(1), 25-30 (2009-01-10)
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Numéro d'article de commerce international

RéférenceGTIN
F7876-25G04061835544936
F7876-10G04061835544912
F7876-1G04061835544929
F7876-100G04061835544905

Questions

1–2 of 2 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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