E0159

Efonidipine hydrochloride monoethanolate

≥98% (HPLC)

• Formule empirique (notation de Hill) : C₃₄H₃₈N₃O₇P · HCl · C₂H₅OH
• Numéro CAS: 111011-76-8
• Poids moléculaire : 714.18
• Numéro MDL: MFCD00875717
• Code UNSPSC : 12352200
• ID de substance PubChem : 329798945
• Nomenclature NACRES : NA.25

Propriétés

• Essai: ≥98% (HPLC)
• Forme: powder
• Conditions de stockage: desiccated
• Couleur: pale yellow
• Solubilité: DMSO: >5 mg/mL; H₂O: insoluble
• Auteur: Shionogi
• Température de stockage: 2-8°C
• Chaîne SMILES: Cl.CCO.CC1=C(C(c2cccc(c2)[N+]([O-])=O)C(=C(C)N1)P3(=O)OCC(C)(C)CO3)C(=O)OCCN(Cc4ccccc4)c5ccccc5
• InChI: 1S/C34H38N3O7P.C2H6O.ClH/c1-24-30(33(38)42-19-18-36(28-15-9-6-10-16-28)21-26-12-7-5-8-13-26)31(27-14-11-17-29(20-27)37(39)40)32(25(2)35-24)45(41)43-22-34(3,4)23-44-45;1-2-3;/h5-17,20,31,35H,18-19,21-23H2,1-4H3;3H,2H2,1H3;1H
• Clé InChI: IKBJGZQVVVXCEQ-UHFFFAOYSA-N

Description

Actions biochimiques/physiologiques

Efonidipine hydrochloride is a racemic compound that has some L-type as well as T-type calcium channel blocking activity.

Racemic efonidipine has both L-type and T-type calcium channel blocking activity. The R(−)-isomer appears to be very selective for T-type calcium channel. The S(+)-isomer inhibits the expressed Ca(V)1.2, Ca(V)1.3 and Ca(V)3.1 channel currents almost equally.

Caractéristiques et avantages

This compound was developed by Shionogi. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)