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C130

Sigma-Aldrich

Chloro-APB hydrobromide

solid

Synonyme(s) :

(±)-6-Chloro-7,8-dihydroxy-3-allyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide, (±)-SKF-82958 hydrobromide, 6-Chloro-N-allyl-SKF-38393 hydrobromide

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About This Item

Formule empirique (notation de Hill):
C19H20ClNO2 · HBr
Numéro CAS:
80751-65-1
Poids moléculaire :
410.73
Numéro MDL:
MFCD00069235
Code UNSPSC :
12352200
ID de substance PubChem :
24277890
Nomenclature NACRES :
NA.77

Forme

solid

Niveau de qualité

100

Couleur

tan

Solubilité

H2O: 3.7 mg/mL
aqueous base: unstable
ethanol: soluble

Température de stockage

2-8°C

Chaîne SMILES 

Br.Oc1cc2C(CN(CCc2c(Cl)c1O)CC=C)c3ccccc3

InChI

1S/C19H20ClNO2.BrH/c1-2-9-21-10-8-14-15(11-17(22)19(23)18(14)20)16(12-21)13-6-4-3-5-7-13;/h2-7,11,16,22-23H,1,8-10,12H2;1H

Clé InChI

WLXGFAVTAAQOFH-UHFFFAOYSA-N

Informations sur le gène

human ... DRD1(1812)

Catégories apparentées

Application

Chloro-APB hydrobromide has been used to pharmacologically stimulate D1 dopamine receptors and study its influence on locomotor response in fat mass and obesity-associated protein (FTO) deficient dopamine D1 receptor-expressing medium spiny neurons (D1 MSNs) of mice.

Actions biochimiques/physiologiques

Chloro-APB hydrobromide, also known as SKF 82958, is a D1 dopamine receptor agonist. D1 receptor agonists prevent and reverse fentanyl-induced respiratory depression, without impairing opioid analgesia, in cats.

Attention

Light sensitive

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

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