03439

N-Ethyldiisopropylamine solution

~2 M in 1-methyl-2-pyrrolidinone, solution, suitable for peptide synthesis

• Synonyme(s) : N,N-Diisopropylethylamine, DIPEA, Hünig’s base
• Formule empirique (notation de Hill) : C₈H₁₉N
• Numéro CAS: 7087-68-5
• Poids moléculaire : 129.24
• NACRES: NA.21
• PubChem Substance ID: 329747633
• UNSPSC Code: 12352100
• MDL number: MFCD00008868
• Beilstein/REAXYS Number: 4124745
• Form: liquid

Propriétés

• Nom du produit: N-Ethyldiisopropylamine solution, suitable for peptide synthesis, ~2 M in 1-methyl-2-pyrrolidinone
• form: liquid
• Quality Segment: 100
• concentration: ~2 M in 1-methyl-2-pyrrolidinone
• impurities: ≤0.2% water (KFT)
• refractive index: n20/D 1.454
• application(s): peptide synthesis
• functional group: amine
• SMILES string: CCN(C(C)C)C(C)C
• InChI: 1S/C8H19N/c1-6-9(7(2)3)8(4)5/h7-8H,6H2,1-5H3
• InChI key: JGFZNNIVVJXRND-UHFFFAOYSA-N

Description

General description

N-Ethyldiisopropylamine (EDIA) reacts with monoactivated Michael acceptors to afford symmetrical sulfones.

Application

N,N-Diisopropylethylamine (DIPEA), also known as Hünig′s base, is a sterically hindered amine. It is commonly employed as a base in peptide synthesis. Additionally, DIPEA is also used in the Pd-catalyzed cross-coupling reactions, which include Heck coupling and Sonagashira coupling reactions.

Informations sur la sécurité

• pictograms: GHS02,GHS06,GHS08,GHS05,GHS09
• signalword: Danger
• hcodes: H226,H302,H315,H318,H331,H335,H360D,H411
• pcodes: P210 - P273 - P280 - P304 + P340 + P311 - P305 + P351 + P338 - P308 + P313
• Hazard Classifications: Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Flam. Liq. 3 - Repr. 1B - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Classe de stockage: 3 - Flammable liquids
• wgk: WGK 2
• flash_point_f: 73.4 °F
• flash_point_c: 23 °C
• ppe: Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter