8.55129
NovaSyn® TG PAP RESIN
Novabiochem®
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Quality Segment
product line
NovaSyn® TG, Novabiochem®
form
beads
reaction suitability
reaction type: Fmoc solid-phase peptide synthesis
manufacturer/tradename
Novabiochem®
application(s)
peptide synthesis
functional group
amine
storage temp.
2-8°C
General description
NovaSyn TG PAP resin contains an acid cleavable linkage between the polystyrene matrix and the PEG chain. Treatment of peptides prepared on this resin with TFA/thioanisole (95:5) for 12 hours or TMSBr/TFA/thioanisole (1:94:5) for 60 minutes releases a fully deprotected peptide possessing a PEG-chain attached to the C-terminus [1]. Such peptide-PEG conjugates can be used directly as immunogens, without the need for a carrier protein. The peptide-PEG conjugates are also highly soluble and provide an effective solution to insoluble peptides.
Associated Protocols and Technical Articles
Protocols for Loading of Peptide Synthesis Resins
Literature references
[1] W. Rapp in ′Combinatorial Peptide and Nonpeptide Libraries′, G. Jung (Eds), Vch, 1996, pp. 425.
Associated Protocols and Technical Articles
Protocols for Loading of Peptide Synthesis Resins
Literature references
[1] W. Rapp in ′Combinatorial Peptide and Nonpeptide Libraries′, G. Jung (Eds), Vch, 1996, pp. 425.
Analysis Note
Colour (visual): white to yellow to beige
Appearance of substance (visual): beads
Loading (determined from the substitution of the Fmoc-Leu loaded resin): 0.20 - 0.30 mmol/g
Swelling Volume (in CH₂Cl₂): lot specific result
Appearance of substance (visual): beads
Loading (determined from the substitution of the Fmoc-Leu loaded resin): 0.20 - 0.30 mmol/g
Swelling Volume (in CH₂Cl₂): lot specific result
Legal Information
NOVASYN is a registered trademark of Merck KGaA, Darmstadt, Germany
Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany
Classe de stockage
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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