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5.31237

IRAK4 Inhibitor, Compound 26

Synonyme(s) :

IRAK4 Inhibitor, Compound 26, Interleukin-1 Receptor Associated Kinase 4 Inhibitor

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ConditionnementRéférenceDisponibilitéPrix
10 mg
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292,00 $

A propos de cet article

Formule empirique (notation de Hill) :
C25H27N5O2
Numéro CAS:
1604034-71-0
Poids moléculaire :
429.51
MDL number:
MFCD09037563
NACRES:
NA.77
UNSPSC Code:
12352200
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
100
Storage condition:
OK to freeze, protect from light

292,00 $

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assay

≥98% (HPLC)

Quality Level

100

form

powder

potency

94 pM IC50

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

pale yellow

solubility

DMSO: 50 mg/mL

storage temp.

2-8°C

General description

A cell permeable indolo[2,3-c]quinoline derivatived compound that acts as a selective and highly potent inhibitor of interleukin-1 receptor associated kinase (IRAK4; IC50 = 94 pM). Displays much reduced potency against IRAK1 (IC50 = 65 nM) and displays high selectivity over a panel of other 27 kinases, including several involved in TLR-mediated signaling. Blocks R848-induced TNF-α and IL-6 production in primary human monocytes and inhibits LPS-induced TNF-α production in mice (100 mpk). Shows minimal inhibition of Cyp2C9, 2D6, and 3A4 and has excellent microsomal stability and desirable aqueous solubility (100 μg/ml at pH 7.4).

Please note that the molecular weight for this compound is batch-specific due to variable water content.

Biochem/physiol Actions

Cell permeable: yes
Primary Target
IRAK4
Reversible: yes

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Tumey, L.N., et al. 2014 Bioorg. Med. Chem. Lett. 24, 2066.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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Cet article
428205-M445835-M07-1601
IRAK4 Inhibitor, Compound 26

Sigma-Aldrich

5.31237

IRAK4 Inhibitor, Compound 26

Lck Inhibitor The Lck Inhibitor, also referenced under CAS 213743-31-8, controls the biological activity of Lck. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Millipore

428205-M

Lck Inhibitor

Mer RTK Inhibitor, UNC569 Mer RTK Inhibitor, UNC569, 1350547-65-7 is a potent, reversible and ATP-competitive inhibitor of Mer receptor tyrosine kinase (IC50 = 2.9 nM; Ki = 4.3 nM).

Millipore

445835-M

Mer RTK Inhibitor, UNC569

Anti-IRAK1 Antibody, CT from rabbit

Sigma-Aldrich

07-1601

Anti-IRAK1 Antibody, CT

form

powder

form

solid

form

powder

form

-

assay

≥98% (HPLC)

assay

≥95% (HPLC)

assay

≥95% (HPLC)

assay

-

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

-

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

-

storage condition

OK to freeze, protect from light

storage condition

OK to freeze, protect from light

storage condition

OK to freeze, protect from light

storage condition

-

Classe de stockage

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Numéro d'article de commerce international

RéférenceGTIN
531237000104055977242706

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