C1063
Gonadotropine chorionique human
lyophilized powder, vial of ~2,500 IU
Synonyme(s) :
Choriogonine, HCG
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A propos de cet article
Biological source:
human urine
Form:
lyophilized powder
Service technique
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human urine
Quality Level
sterility
sterile-filtered
form
lyophilized powder
mol wt
37.9 kDa
contains
mannitol
packaging
vial of ~2,500 IU
drug control
Home Office Schedule 4.2
impurities
HBsAg, HCV and HIV-1/HIV-2, tested negative
solubility
water: 10 mL/vial, clear, colorless
UniProt accession no.
shipped in
ambient
storage temp.
−20°C
Gene Information
human ... CGA(1081)
General description
Hormone glycoprotéique consistant en une chaîne α de 92 acides aminés identique à celle de la LH, la FSH et la TSH, et en une chaîne β de 149 acides aminés. Produite par les tissus chorioniques et responsable du maintien du corps jaune en début de grossesse. Également produite par les tumeurs trophoblastiques, qui se distinguent par une présence anormalement élevée de chaînes de hCG β et une hCG hyperglycosylée.
Application
Chorionic gonadotropin human has been used in the biological validation of urinary testosterone (UTM) and urinary estradiol metabolites (UEM) EIA and superovulation.
Biochem/physiol Actions
Human chorionic gondadotropin (hCG) may be used as an alternative to PMSG to induce ovulation in laboratory animals. When hCG was injected into laboratory animals via intravenous (i.v.), intraperitoneal (i.p.), or subcutaneous (s.c.) methodstet, the effective dose values for 50% of the animals (ED50) per animal and per body weight (kg) in parenthesis were as follows:
Mice: i.v. 0.2 (7.7) I.U.; i.p. 0.3 (11.5) I.U.; s.c. 0.7 (26.9) I.U.
Syrian hamsters: i.v. 1.0 (9.5) I.U.; i.p. 1.8 (17.1) I.U.; s.c. 2.6 (24.8) I.U.
Rats: i.v. 1.3 (4.6) I.U.; i.p. 3.5 (12.3) I.U.; s.c.7.5 (26.3) I.U.
Using PMSG, the ED50 values per animal and per body weight (kg) in parenthesis were as follows:
Mice: i.v. 0.8 (30.8) I.U.; i.p. 2.0 (76.9) I.U.; s.c. 2.8 (107.7) I.U
Syrian hamsters: i.v., 3.6 (34.3) I.U.; i. p., 8.0 (76.2) I.U.; s.c., 13.2 (125.7) I.U.
Rats: i.v., 6.0 (76.8) I.U.; i p., 20.8 (73.0) I.U.; s.c., 76.8 (269.5) I.U.
Mice: i.v. 0.2 (7.7) I.U.; i.p. 0.3 (11.5) I.U.; s.c. 0.7 (26.9) I.U.
Syrian hamsters: i.v. 1.0 (9.5) I.U.; i.p. 1.8 (17.1) I.U.; s.c. 2.6 (24.8) I.U.
Rats: i.v. 1.3 (4.6) I.U.; i.p. 3.5 (12.3) I.U.; s.c.7.5 (26.3) I.U.
Using PMSG, the ED50 values per animal and per body weight (kg) in parenthesis were as follows:
Mice: i.v. 0.8 (30.8) I.U.; i.p. 2.0 (76.9) I.U.; s.c. 2.8 (107.7) I.U
Syrian hamsters: i.v., 3.6 (34.3) I.U.; i. p., 8.0 (76.2) I.U.; s.c., 13.2 (125.7) I.U.
Rats: i.v., 6.0 (76.8) I.U.; i p., 20.8 (73.0) I.U.; s.c., 76.8 (269.5) I.U.
Preparation Note
When reconstituted with water to a concentration of 1,000 IU/mL, the vial will also contain 0.04 M sodium phosphate buffer (pH approx. 7.2) and 40 mg/mL of mannitol.
Analysis Note
The calculated value is based on the USP method for human Chorionic Gonadotrophin, to meet 2,500 IU per vial, with a tolerance of not less than 80.0% and not more than 125.0% of the potency stated.
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Classe de stockage
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
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Contenu apparenté
Luqing Zhang et al.
PloS one, 10(3), e0120396-e0120396 (2015-03-25)
ZFN, TALENs and CRISPR/Cas9 system have been used to generate point mutations and large fragment deletions and insertions in genomic modifications. CRISPR/Cas9 system is the most flexible and fast developing technology that has been extensively used to make mutations in
Interrelationship among annual cycles of sex steroids, corticosterone and body condition in Nyctibatrachus humayuni
Joshi AM, et al.
General and Comparative Endocrinology, 260, 151-160 (2018)
Emmet L Guy et al.
Conservation physiology, 8(1), coz113-coz113 (2020-01-16)
Many amphibian species reinitiate the processes of preparing for reproduction (e.g. oogenesis) soon after breeding indicating hormone-induced ovulation could potentially be achieved out-of-season, which would lead to higher annual fecundity compared to mono-seasonal breeding. Such strategies would be beneficial to
Numéro d'article de commerce international
| Référence | GTIN |
|---|---|
| C1063-10VL | 04061833460641 |
| C1063-1VL | 04061833460658 |