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E7280

Sigma-Aldrich

Elafin

recombinant, expressed in Saccharomyces cerevisiae, powder, >90% (by MS, HPLC and SDS-PAGE),

Synonyme(s) :

Elastase-specific inhibitor, skin-derived antileukoprotease

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About This Item

Numéro MDL:
MFCD00146824
Code UNSPSC :
12352202
Nomenclature NACRES :
NA.77

product name

Elafin human, >90% (by MS, HPLC and SDS-PAGE), recombinant, expressed in Saccharomyces cerevisiae

Produit recombinant

expressed in Saccharomyces cerevisiae

Niveau de qualité

200

Pureté

>90% (by MS, HPLC and SDS-PAGE)

Forme

powder

Puissance

1.7 x 10-10 M Ki (human leukocyte elastase)
4.2 x 10-10 M Ki (human proteinase 3)

Poids mol.

~6 kDa

Numéro d'accès UniProt

P19957

Spectre d'activité de l'antibiotique

Gram-negative bacteria
Gram-positive bacteria

Mode d’action

enzyme | inhibits

Conditions d'expédition

ambient

Température de stockage

−20°C

Informations sur le gène

human ... PI3(5266)

Description générale

Chemical structure: peptide

Actions biochimiques/physiologiques

Inhibitor of human leukocyte elastase and proteinase 3, originally isolated from the skin of patients with psoriasis. May protect against certain autoimmune tissue damage. An elastase inhibitor which is an active fragment of elafin, as well as elafin itself, can also be found in bronchial carcinoma secretions.
Exhibits co-existent antimicrobial and antiproteolytic activities.1 Inhibits WAP-type four-disulfide core (WFDC) domain containing elastases. Antimicrobial spectrum: Gram-positive and Gram-negative bacteria.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

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Renata Curciarello et al.
Journal of inflammation research, 13, 233-243 (2020-06-18)
Proteases play an essential role in the pathophysiology of inflammatory bowel disease (IBD), contributing to the intestinal mucosal lesions through the degradation of the extracellular matrix and alteration of the barrier function. Ulcerative colitis (UC) is characterized by an extensive
Lingling Shu et al.
Clinical science (London, England : 1979), 134(13), 1679-1696 (2020-07-08)
Type 1 diabetes is an autoimmune disease resulted from self-destruction of insulin-producing pancreatic β cells. However, the pathological pathways that trigger the autoimmune destruction remain poorly understood. Clinical studies have demonstrated close associations of neutrophils and neutrophil elastase (NE) with
T Dau et al.
Scientific reports, 6, 35413-35413 (2016-10-16)
High abundance proteins like protease inhibitors of plasma display a multitude of interactions in natural environments. Quantitative analysis of such interactions in vivo is essential to study diseases, but have not been forthcoming, as most methods cannot be directly applied
Viraj J Jasinghe et al.
BioResearch open access, 2(2), 128-137 (2013-04-18)
Trappin-2/elafin is a novel innate immune factor that belongs to the serine protease inhibitor family and has known antibacterial, antifungal, and antiviral properties. In this study, we further investigated the anti-HIV activity of elafin using different cellular models and both
Jiani Wang et al.
Scientific reports, 10(1), 12785-12785 (2020-08-01)
Elafin is an antimicrobial and anti-inflammatory protein. We hypothesize that elafin expression correlates with diabetes. Among non-diabetic and prediabetic groups, men have significantly higher serum elafin levels than women. Men with type 2 diabetes mellitus (T2DM) have significantly lower serum
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Articles

Elastase Function and Importance

Elastase application index for understanding leukocyte elastase, a 29KDa serine endoprotease.

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