D3071
Dipeptidyl Peptidase IX human
recombinant, expressed in Sf9 cells
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| Conditionnement | Référence | Disponibilité | Prix |
|---|---|---|---|
| 10 μg | Veuillez contacter notre Service Clients pour connaître la disponibilité de ce produit. | 662,00 € |
A propos de cet article
NACRES:
NA.54
UNSPSC Code:
12352204
Specific activity:
≥250 units/μg protein
Recombinant:
expressed in Sf9 cells
662,00 €
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Laissez-nous vous aiderrecombinant
expressed in Sf9 cells
Quality Level
form
solution
specific activity
≥250 units/μg protein
shipped in
dry ice
storage temp.
−70°C
General description
Full length sequence with an N-terminal GST tag
Application
Biochem/physiol Actions
DPP IX is a member of the S9b family of dipeptidyl peptidases and cleaves the peptide hormones glucagon-like peptide-1, glucagon-like peptide-2, neuropeptide Y and peptide YY with marked kinetic differences compared with dipeptidyl peptidase IV. It has a role in regulating cell survival and proliferation through modulating molecular signaling cascades. Protein kinase B activation is significantly inhibited by human DPP9 overexpression in human hepatoma cells (HepG2 and Huh7) and human embryonic kidney cells (HEK293T)[1]. DPP9 is thought to influence cell-extracellular matrix interactions and may be involved in the regulation of tissue remodeling [2].
Physical form
Supplied as a solution in 40 mM Tris-HCl pH 8.0, 110 mM NaCl, 2.2 mM KCl, 20% glycerol, 3 mM DTT, and 16 mM glutathione
Other Notes
DPP IX is a member of the S9b family of dipeptidyl peptidases. and cleaves the peptide hormones glucagon-like peptide-1, glucagon-like peptide-2, neuropeptide Y and peptide YY with marked kinetic differences compared with dipeptidyl peptidase IV.
One unit will hydrolyze 1.0 picomole of H-Gly-Pro-AMC per minute at pH 7.5 at 25 deg °C
1 of 1
Cet article | |||
|---|---|---|---|
| specific activity ≥250 units/μg protein | specific activity ≥20 units/μg protein | specific activity ≥1,500 units/μg protein, ≥1500 units/μg protein | specific activity ≥400 units/μg protein |
| form solution | form solution | form solution | form solution |
| recombinant expressed in Sf9 cells | recombinant expressed in Sf9 cells | recombinant expressed in Sf9 cells | recombinant expressed in Sf9 cells |
| storage temp. −70°C | storage temp. −70°C | storage temp. −70°C | storage temp. −70°C |
| shipped in dry ice | shipped in dry ice | shipped in dry ice | shipped in dry ice |
| Quality Level 200 | Quality Level 200 | Quality Level 200 | Quality Level 200 |
Classe de stockage
10 - Combustible liquids
wgk
WGK 1
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Tsun-Wen Yao et al.
Molecular cancer research : MCR, 9(7), 948-959 (2011-05-31)
Dipeptidyl peptidase IV (DPP4), DPP8, DPP9, and fibroblast activation protein (FAP), the four proteases of the DPP4 gene family, have unique peptidase and extra-enzymatic activities that have been implicated in various diseases including cancers. We report here a novel role
Denise M T Yu et al.
The FEBS journal, 273(11), 2447-2460 (2006-05-18)
The dipeptidyl peptidase IV gene family contains the four peptidases dipeptidyl peptidase IV, fibroblast activation protein, dipeptidyl peptidase 8 and dipeptidyl peptidase 9. Dipeptidyl peptidase IV and fibroblast activation protein are involved in cell-extracellular matrix interactions and tissue remodeling. Fibroblast
Numéro d'article de commerce international
| Référence | GTIN |
|---|---|
| D3071-10UG | 04061832700472 |