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72335

9-(2,2-Dicyanovinyl)julolidine

Name: 9-(2,2-Dicyanovinyl)julolidine
Brand: SIGMA

BioReagent, suitable for fluorescence, ≥97.0% (HPLC)

Synonyme(s) :

9-Julolidinylmethylenemalononitrile, DCVJ

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Conditionnement	Référence	Disponibilité	Prix

A propos de cet article

Formule empirique (notation de Hill) :

C₁₆H₁₅N₃

Numéro CAS:

58293-56-4

Poids moléculaire :

249.31

UNSPSC Code:

12352108

NACRES:

NA.32

PubChem Substance ID:

57652412

MDL number:

MFCD01747392

Beilstein/REAXYS Number:

413882

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Propriétés

product line

BioReagent

Quality Segment

100

assay

≥97.0% (HPLC)

form

crystals

solubility

DMSO: soluble, chloroform: soluble

fluorescence

λ_ex 433 nm; λ_em 500 nm in 50 mM Tris pH 8.0; 40% glycerol

suitability

suitable for fluorescence

SMILES string

N#C\C(=C/c1cc2CCCN3CCCc(c1)c23)C#N

InChI

1S/C16H15N3/c17-10-13(11-18)7-12-8-14-3-1-5-19-6-2-4-15(9-12)16(14)19/h7-9H,1-6H2

InChI key

LROAUBRDKLVBCP-UHFFFAOYSA-N

Description

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Other Notes

Fluorescent probe for binding to proteins etc., quantum yield increases by decreasing free rotation; abs at ~450 nm, em at 480-505 nm (solvent dep.)[1][2]

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Cet article	72301	36799	21882
Sigma-Aldrich 72335 9-(2,2-Dicyanovinyl)julolidine	Sigma-Aldrich 72301 9-(2-Carboxy-2-cyanovinyl)julolidine	Sigma-Aldrich 36799 7-(Diethylamino)coumarin-3-carboxylic acid	Sigma-Aldrich 21882 5(6)-Carboxy-2′,7′-dichlorofluorescein
suitability suitable for fluorescence	suitability suitable for fluorescence	suitability suitable for fluorescence	suitability suitable for fluorescence
fluorescence λ_ex 433 nm; λ_em 500 nm in 50 mM Tris pH 8.0; 40% glycerol	fluorescence λ_ex 433 nm; λ_em 500 nm in 50 mM Tris pH 8.0; 40% glycerol	fluorescence λ_ex 409 nm; λ_em 473 nm in 0.1 M Tris pH 9.0	fluorescence λ_ex 504 nm; λ_em 529 nm in 0.1 M Tris pH 8.0
solubility DMSO: soluble, chloroform: soluble	solubility DMSO: soluble, chloroform: soluble	solubility DMF: soluble, DMSO: soluble	solubility DMF: soluble, DMSO: soluble, H₂O: soluble (pH ≥ 5)
form crystals	form solid	form -	form solid
assay ≥97.0% (HPLC)	assay ≥97.0% (HPLC)	assay ≥98.0% (HPCE)	assay ≥95% (TLC)
product line BioReagent	product line BioReagent	product line BioReagent	product line BioReagent

Classe de stockage

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Fluorescent molecular rotors as dyes to characterize polysorbate-containing IgG formulations.

Andrea Hawe et al.

Pharmaceutical research, 27(2), 314-326 (2009-12-31)

The aim was to evaluate fluorescent molecular rotors (DCVJ and CCVJ), which are mainly sensitive to viscosity, for the characterization of polysorbate-containing IgG formulations and compare them to the polarity-sensitive dyes ANS, Bis-ANS and Nile Red. IgG formulations with polysorbate

Fluid shear stress increases membrane fluidity in endothelial cells: a study with DCVJ fluorescence.

M A Haidekker et al.

American journal of physiology. Heart and circulatory physiology, 278(4), H1401-H1406 (2000-04-06)

Fluid shear stress (FSS) has been shown to be an ubiquitous stimulator of mammalian cell metabolism. Although many of the intracellular signal transduction pathways have been characterized, the primary mechanoreceptor for FSS remains unknown. One hypothesis is that the cytoplasmic

Fluorescence energy transfer measurement of distances between ligand binding sites of tubulin and its implication for protein-protein interaction.

A Bhattacharya et al.

Protein science : a publication of the Protein Society, 5(10), 2029-2036 (1996-10-01)

9-(Dicyanovinyl) julolidine (DCVJ) is a fluorescent probe, which binds to a unique site on the tubulin dimer and exhibits different properties that are dependent upon its oligomeric state (Kung & Reed, 1989). DCVJ binds to tubulin, the tubulin-colchicine complex, and

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Numéro d'article de commerce international

Référence	GTIN
72335-5MG	04061834370659

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