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D9302

Diacerein

≥95% (HPLC)

Synonyme(s) :

1,8-Diacetoxy-3-carboxyanthraquinone

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A propos de cet article

Formule empirique (notation de Hill) :
C19H12O8
Numéro CAS:
Poids moléculaire :
368.29
NACRES:
NA.25
PubChem Substance ID:
UNSPSC Code:
41116107
EC Number:
237-310-2
MDL number:
Assay:
≥95% (HPLC)
Form:
powder
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assay

≥95% (HPLC)

form

powder

SMILES string

CC(=O)Oc1cccc2C(=O)c3cc(cc(OC(C)=O)c3C(=O)c12)C(O)=O

InChI

1S/C19H12O8/c1-8(20)26-13-5-3-4-11-15(13)18(23)16-12(17(11)22)6-10(19(24)25)7-14(16)27-9(2)21/h3-7H,1-2H3,(H,24,25)

InChI key

TYNLGDBUJLVSMA-UHFFFAOYSA-N

Biochem/physiol Actions

Diacerin is an inhibitor of Interleukin-1B (IL-1B) production.


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pictograms

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signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Classe de stockage

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves



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Numéro d'article de commerce international

RéférenceGTIN
D9302-50MG04061833590591

Questions

1–5 of 5 Questions  
  1. What is the melting point of Product D9302, Diacerein?

    1 answer
    1. The chemicals encyclopedia published by the Royal Society of Chemistry (11th ed., entry #2939) reports a melting point of 217-218°C.

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  2. Can Product D9302, Diacerein, be dissolved in DMSO?

    1 answer
    1. Yes. Diacerein is soluble in DMSO at 1 mg/mL.  The compound is also soluble in acetic acid at a concentration of 25 mg in 8 mL, as stated on the specification sheet.

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  3. What is the biological activity of Product D9302, Diacerein?

    1 answer
    1. Martindale, 30th ed. indicates that "Diacerein is a non-steroidal anti-inflammatory agent that has been used in musculoskeletal and joint disorders."  Diacerein acts by inhibiting interleukin-1. The chemicals encyclopedia published by the Royal Society of Chemistry, 11th ed., indicates that Diacerein "demonstrates anti-arthritic activity without inhibiting prostaglandin synthesis".

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  4. What is the Department of Transportation shipping information for this product?

    1 answer
    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

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  5. What is the mechanism of action of Product D9302, Diacerein?

    1 answer
    1. "Diacerein is a slow acting symptomatic treatment of osteoarthritis which has demonstrated efficacy on functional manifestations of osteoarthritis and on the structural component. Two mechanisms of action have been validated: in vitro inhibition of interleukin-1 (IL-1) synthesis, the main cytokine involved in cartilage destruction, and activity on the synthesis of proteoglycans, and hyaluronic acid, the principal component of cartilage. Other studies presented here have provided further details concerning other mechanisms of action of diacerein", according to Presse Med., 33(9 Pt 2), S10-S12 (2004).

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