Accéder au contenu
Merck

Principaux documents

Voir toute la documentation

Passer à

B4563

Bisantrene dihydrochloride

≥98% (HPLC)

Synonyme(s) :

Bis((4,5-dihydro-1H-imidazol-2-yl)hydrazone)-9,10-anthracenedicarboxaldehyde dihydrochloride, NSC 337766

Se connecter pour consulter les tarifs organisationnels et contractuels.

Sélectionner une taille de conditionnement

Changer de vue
ConditionnementRéférenceDisponibilitéPrix
10 mg
Veuillez contacter notre Service Clients pour connaître la disponibilité de ce produit.
87,50 €
50 mg
Veuillez contacter notre Service Clients pour connaître la disponibilité de ce produit.
333,00 €

A propos de cet article

Formule empirique (notation de Hill) :
C22H22N8 ·2HCl
Numéro CAS:
78186-34-2
Poids moléculaire :
471.39
NACRES:
NA.77
PubChem Substance ID:
329773240
UNSPSC Code:
12352200
MDL number:
MFCD01743164
Assay:
≥98% (HPLC)
Form:
solid
Quality level:
100
Storage condition:
desiccated

87,50 €

Veuillez contacter notre Service Clients pour connaître la disponibilité de ce produit.
​
Demander une commande groupée
Service technique
Besoin d'aide ? Notre équipe de scientifiques expérimentés est là pour vous.
Laissez-nous vous aider

Quality Level

100

assay

≥98% (HPLC)

form

solid

storage condition

desiccated

solubility

deionized water: 8 mg/mL

storage temp.

room temp

SMILES string

Cl.Cl.C1CN=C(N1)N\N=C\c2c3ccccc3c(\C=N\NC4=NCCN4)c5ccccc25

InChI

1S/C22H22N8.2ClH/c1-2-6-16-15(5-1)19(13-27-29-21-23-9-10-24-21)17-7-3-4-8-18(17)20(16)14-28-30-22-25-11-12-26-22;;/h1-8,13-14H,9-12H2,(H2,23,24,29)(H2,25,26,30);2*1H/b27-13+,28-14+;;

InChI key

KINULKKPVJYRON-PVNXHVEDSA-N

Application

Bisantrene (NSC 337766), and its derivatives are topoisomerase II poisons and DNA intercalators. It may be used as model compounds to study P-glycoprotein-mediated multiple drug resistance (MDR1). Bisantrene may be used as a Rac1 inhibitor.

Biochem/physiol Actions

Bisantrene dihydrochloride is an antineoplastic agent, MDR1 substrate, DNA intercalator and topoisomerase II poison
Bisantrene dihydrochloride is an antineoplastic agent, MDR1 substrate, DNA intercalator, and topoisomerase II poison. Cancer cells that develop resistance to bisantrene tend to overexpress P-glycoprotein. Bisantrene can be used to select for P-glycoprotein-mediated multiple drug resistance. The data suggest that bisantrene is an excellent substrate for P-glycoprotein.
Bisantrene is an anthracene bishydrazone derivative, which has antitumor activity.

Comparer avec des articles similaires

Voir la comparaison complète

Montrer les différences

1 of 1

Cet article
B7283SML1703T6950
Bisantrene dihydrochloride ≥98% (HPLC)

Sigma-Aldrich

B4563

Bisantrene dihydrochloride

Benserazide hydrochloride ≥98% (HPLC), solid

Sigma-Aldrich

B7283

Benserazide hydrochloride

2-BFI hydrochloride ≥98% (HPLC)

Sigma-Aldrich

SML1703

2-BFI hydrochloride

Tizanidine hydrochloride ≥98% (HPLC), powder

Sigma-Aldrich

T6950

Tizanidine hydrochloride

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

form

solid

form

solid

form

powder

form

powder

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

room temp

storage temp.

room temp

storage temp.

2-8°C

storage temp.

-

storage condition

desiccated

storage condition

-

storage condition

desiccated

storage condition

desiccated

solubility

deionized water: 8 mg/mL

solubility

H2O: 10 mg/mL

solubility

DMSO: 20 mg/mL, clear

solubility

H2O: >20 mg/mL

pictograms

Exclamation markEnvironment
GHS07,GHS09

signalword

Warning

hcodes

H302,H400

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1

Classe de stockage

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Faites votre choix parmi les versions les plus récentes :

Certificats d'analyse (COA)

Lot/Batch Number
0000471323
0000204003
0000204001
030M4627V
0000204003

Vous ne trouvez pas la bonne version ?

Si vous avez besoin d'une version particulière, vous pouvez rechercher un certificat spécifique par le numéro de lot.

Rechercher un(e) COA

Déjà en possession de ce produit ?

Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

I Aksentijevich et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 2(6), 973-980 (1996-06-01)
In this work, we demonstrate a protective effect conferred by the human multidrug resistance gene (MDR1) to populations of the murine hematopoietic system against the toxic effects of bisantrene, a novel intercalating cytotoxic agent under investigation as an anticancer agent.
G M Mills et al.
American journal of clinical oncology, 12(6), 507-510 (1989-12-01)
Twenty-nine patients with heavily pretreated acute leukemia in relapse were treated with bisantrene (maximum dose 120 mg/m2/day x 5) in a phase II study. Twenty-seven of the 29 patients were evaluable for response, receiving a total of 53 courses of
T Leblanc et al.
Medical and pediatric oncology, 22(2), 119-124 (1994-01-01)
Bisantrene is an anthracene derivative which has demonstrated activity in acute myeloblastic leukemia (AML) and in lymphoma. The present study was designed to assess the reinduction rate and toxicity of bisantrene (250 mg/m2/d x 5) associated with aracytine (100 mg/m2
Afficher tous les articles scientifiques apparentés

Numéro d'article de commerce international

RéférenceGTIN
B4563-50MG04061833228517
B4563-10MG04061833228500

Questions

Reviews

No rating value

Active Filters