370656

Guanosine 3′,5′-cyclic Monophosphate, Sodium Salt

Important intracellular second messenger implicated in the action of nitric oxide in many cell types.

• Sinónimos: Guanosine 3′,5′-cyclic Monophosphate, Sodium Salt, Cyclic GMP, G-3,5-MP, cGMP, Na
• Fórmula empírica (notación de Hill): C₁₀H₁₁N₅O₇P · Na
• Número CAS: 40732-48-7
• Peso molecular: 367.19
• UNSPSC Code: 41106305
• NACRES: NA.77
• MDL number: MFCD00038424
• Assay: >98% (HPLC)
• Form: solid
• Storage condition: OK to freeze, desiccated (hygroscopic)

Propiedades

• Quality Segment: 100
• description: Merck USA index - 14, 2709
• assay: >98% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, desiccated (hygroscopic)
• color: white
• solubility: water: 1 mg/mL
• shipped in: ambient
• storage temp.: −20°C
• SMILES string: [Na+].[P]1(=O)(O[C@@H]2[C@H](O[C@H]([C@@H]2O)[n]3c4nc(nc(c4nc3)[O-])N)CO1)O
• InChI: 1S/C10H12N5O7P.Na/c11-10-13-7-4(8(17)14-10)12-2-15(7)9-5(16)6-3(21-9)1-20-23(18,19)22-6;/h2-3,5-6,9,16H,1H2,(H,18,19)(H3,11,13,14,17);/q;+1/p-1/t3-,5-,6-,9-;/m1./s1
• InChI key: KMPIYXNEROUNOG-GWTDSMLYSA-M

Descripción

General description

An important intracellular second messenger implicated in mediating the action of nitric oxide in many cell types. Found to activate protein kinase G. Suppresses apoptosis in rat ovarian follicles.

Important intracellular second messenger implicated in the action of nitric oxide in many cell types. Activates protein kinase G. Suppresses apoptosis in rat ovarian follicles.

Biochem/physiol Actions

Primary Target
Activates protein kinase G

Product does not compete with ATP.

Reversible: no

Cell permeable: no

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.

Other Notes

Chun, S.Y., et al. 1995. Endocrinology136, 3120.
Kaupp, U.B., and Koch, K.W. 1992. Annu. Rev. Physiol.54, 153.
Goldberg, N.D., and Haddox, M.K. 1977. Annu. Rev. Biochem. 46, 823.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Información de seguridad

• Clase de almacenamiento: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable