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P8296

5-Phospho-D-ribose 1-diphosphate pentasodium salt

≥75% (HPLC)

Sinónimos:

α-D-Ribosyl diphosphate 5-phosphate pentasodium salt, 5-Phospho-α-D-ribosyl diphosphate, 5-Phosphoribosyl 1-pyrophosphate pentasodium salt, P-Rib-PP, PRPP pentasodium salt

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Acerca de este artículo

Fórmula empírica (notación de Hill):
C5H8Na5O14P3
Número CAS:
108321-05-7
Peso molecular:
499.98
UNSPSC Code:
12352201
NACRES:
NA.25
PubChem Substance ID:
24898743
MDL number:
MFCD32182529
Beilstein/REAXYS Number:
6043637
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Quality Level

300

assay

≥75% (HPLC)

form

powder

impurities

<18% water (Karl Fischer)

color

white

solubility

water: 50 mg/mL, clear to slightly hazy, colorless to very faintly yellow

shipped in

dry ice

storage temp.

−20°C

SMILES string

[Na+].[Na+].[Na+].[Na+].O[C@H]1[C@@H](O)[C@H](O[C@@H]1COP(O)([O-])=O)OP([O-])(=O)OP([O-])([O-])=O

InChI

1S/C5H13O14P3.4Na/c6-3-2(1-16-20(8,9)10)17-5(4(3)7)18-22(14,15)19-21(11,12)13;;;;/h2-7H,1H2,(H,14,15)(H2,8,9,10)(H2,11,12,13);;;;/q;4*+1/p-4/t2-,3-,4-,5?;;;;/m1..../s1

InChI key

QZAPPJHVNYCTAX-CKJQBBATSA-J

General description

Substrate for phosphoribosyltransferases in the synthesis of nucleotides.

Application

Pentasodium salt has been used in a study to assess the relationship between the muscarinic receptor cationic current and internal calcium in guinea-pig jejunal smooth muscle cells. [1] It has also been used in a study to investigate inhibitors of the bacterial cell wall biosynthesis of the enzyme Mur D. [2]

Analysis Note

Purity ≥ 75% based on an assay system using orotidine-5′-phosphate pyrophosphorylase and orotidine-5′-phosphate decarboxylase mixed enzymes.

Other Notes

To gain a comprehensive understanding of our extensive range of Monosaccharides for your research, we encourage you to visit our Carbohydrates Category page.

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Este artículo
D4022B6149R7750
5-Phospho-D-ribose 1-diphosphate pentasodium salt &#8805;75% (HPLC)

Sigma-Aldrich

P8296

5-Phospho-D-ribose 1-diphosphate pentasodium salt

P1,P5-Di(adenosine-5&#8242;) pentaphosphate pentasodium salt &#8805;95% (HPLC), powder

Sigma-Aldrich

D4022

P1,P5-Di(adenosine-5′) pentaphosphate pentasodium salt

5-Bromo-4-chloro-3-indolyl phosphate disodium salt &#8805;98% (HPLC)

Sigma-Aldrich

B6149

5-Bromo-4-chloro-3-indolyl phosphate disodium salt

D-Ribose 5-phosphate disodium salt hydrate &#8805;98% (TLC), powder

Sigma-Aldrich

R7750

D-Ribose 5-phosphate disodium salt hydrate

assay

≥75% (HPLC)

assay

≥95% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (TLC)

Quality Level

300

Quality Level

200

Quality Level

200

Quality Level

200

solubility

water: 50 mg/mL, clear to slightly hazy, colorless to very faintly yellow

solubility

H2O: 50 mg/mL

solubility

H2O: 20 mg/mL, DMF: insoluble

solubility

water: 50 mg/mL, clear, colorless

form

powder

form

powder

form

powder

form

powder

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

color

white

color

white to yellow-white

color

-

color

white

pictograms

Health hazard
GHS08

signalword

Warning

hcodes

H371

pcodes

P260

Hazard Classifications

STOT SE 2

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certificados de análisis (COA)

Lot/Batch Number
0000530561
0000530560
0000530561
0000530560
0000492145

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L D Gegnas et al.
Bioorganic & medicinal chemistry letters, 8(13), 1643-1648 (1999-01-05)
A series of transition-state analog inhibitors of the D-glutamic acid-adding enzyme (MurD) of bacterial peptidoglycan biosynthesis has been synthesized and evaluated for inhibition of the E. coli enzyme.
P Pacaud et al.
The Journal of physiology, 441, 477-499 (1991-09-01)
1. The action of carbachol, which activates muscarinic receptors, was studied in single patch-clamped cells where free internal calcium concentration in the cell (Cai2+) was estimated using the emission from the dye Indo-1. Cells were dialysed with potassium-free caesium solution
Nisreen Wahwah et al.
Scientific reports, 10(1), 19907-19907 (2020-11-18)
Cisplatin is a mainstay of cancer chemotherapy. It forms DNA adducts, thereby activating poly(ADP-ribose) polymerases (PARPs) to initiate DNA repair. The PARP substrate NAD+ is synthesized from 5-phosphoribose-1-pyrophosphate (PRPP), and we found that treating cells for 6 h with cisplatin reduced
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SKUGTIN
P8296-250MG04061832392677
P8296-25MG04061834401285
P8296-100MG04061834401278
P8296-500MG04061834401292

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