UC430

1′-Hydroxymidazolam

≥97% (HPLC), powder

• Sinónimos: 8-Chloro-6-(2-fluorophenyl)-1-hydroxymethyl-4H-imidazo[1,5a][1,4]benzodiazepine
• Fórmula empírica (notación de Hill): C₁₈H₁₃ClFN₃O
• Número CAS: 59468-90-5
• Peso molecular: 341.77
• UNSPSC Code: 12161501
• PubChem Substance ID: 24724655
• NACRES: NA.77
• MDL number: MFCD00871458
• Form: powder

Propiedades

• Nombre del producto: 1′-Hydroxymidazolam,
• form: powder
• Quality Segment: 200
• drug control: regulated under CDSA - not available from Sigma-Aldrich Canada
• color: white to off-white
• storage temp.: 2-8°C
• SMILES string: OCc1ncc2CN=C(c3ccccc3F)c4cc(Cl)ccc4-n12
• InChI: 1S/C18H13ClFN3O/c19-11-5-6-16-14(7-11)18(13-3-1-2-4-15(13)20)22-9-12-8-21-17(10-24)23(12)16/h1-8,24H,9-10H2
• InChI key: QHSMEGADRFZVNE-UHFFFAOYSA-N

Descripción

General description

1′-Hydroxymidazolam is the metabolite of midazolam.

Application

1′-Hydroxymidazolam (1′-OHMDZ) can be used for assessing Cyp3a11 enzyme activity as well as for pharmacokinetic (PK) study of midazolam.[1]

CYP3A4 metabolite of midazolam.

Biochem/physiol Actions

1′-Hydroxymidazolam is the major hydroxylated metabolite of Midazolam (MDZ), forms due to rapid and extensive metabolization of MDZ by the CYP 450 3A isoenzymes in the liver. The product contributes to the pharmacological impact of MDZ.[2]

Features and Benefits

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Información de seguridad

• Clase de almacenamiento: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)