S6319

Sertraline hydrochloride

≥98% (HPLC), Selective serotonin reuptake inhibitor (SSRI), powder

• Sinónimos: Sertraline HCl, (1S,4S)-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthalenamine hydrochloride
• Fórmula empírica (notación de Hill): C₁₇H₁₇NCl₂ · HCl
• Número CAS: 79559-97-0
• Peso molecular: 342.69
• UNSPSC Code: 12352200
• PubChem Substance ID: 24278601
• NACRES: NA.77
• MDL number: MFCD00895772
• Assay: ≥98% (HPLC)
• Form: powder
• Quality level: 100
• Storage condition: desiccated

Propiedades

• Nombre del producto: Sertraline hydrochloride, ≥98% (HPLC)
• Quality Level: 100
• assay: ≥98% (HPLC)
• form: powder
• optical activity: [α]/D +33 to +43°, c = 2.0 in methanol
• storage condition: desiccated
• color: white
• solubility: DMSO: >20 mg/mL
• SMILES string: ClC1=C(Cl)C=CC([C@H]2C3=C(C=CC=C3)[C@@H](NC)CC2)=C1.[H]Cl
• InChI: 1S/C17H17Cl2N.ClH/c1-20-17-9-7-12(13-4-2-3-5-14(13)17)11-6-8-15(18)16(19)10-11;/h2-6,8,10,12,17,20H,7,9H2,1H3;1H/t12-,17-;/m0./s1
• InChI key: BLFQGGGGFNSJKA-XHXSRVRCSA-N
• Gene Information: human ... HTR1A(3350), HTR1B(3351), HTR1D(3352), HTR1E(3354), HTR1F(3355), HTR2A(3356), HTR2B(3357), HTR2C(3358), HTR3A(3359), HTR3B(9177), HTR3C(170572), HTR3D(200909), HTR3E(285242), HTR4(3360), HTR5A(3361), HTR5B(645694), HTR6(3362), HTR7(3363), SLC6A4(6532)

Descripción

Application

The effect of exposure of sertraline hydrochloride was studied in chronically prepared ovine fetus.[1] It was used in glucocorticoid function assay to study the effect of antidepressants on glucocorticoid receptor function in humans.[2]

Biochem/physiol Actions

Selective serotonin reuptake inhibitor, antidepressant.

Sertraline suppresses platelet function and exhibits antiplatelet and endothelium protective functions. It relieves depression and improves the quality of life in patients with cardiovascular disorders.[3][4] It can also be prescribed to treat depression in Parkinson′s disease.[5]

Features and Benefits

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Información de seguridad

• pictograms: GHS08,GHS07,GHS09
• signalword: Warning
• hcodes: H302,H373,H410
• pcodes: P260 - P264 - P270 - P273 - P301 + P312 - P314
• Hazard Classifications: Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - STOT RE 2
• Clase de almacenamiento: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)