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Documentos

S3672

Sigma-Aldrich

[Sar9, Met(O2)11]-Substance P

≥95% (HPLC)

Sinónimos:

Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Sar-Leu-Met[O2]-NH2

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About This Item

Fórmula empírica (notación de Hill):
C64H100N18O15S
Número de CAS:
110880-55-2
Peso molecular:
1393.66
MDL number:
MFCD00076787
UNSPSC Code:
12352209
PubChem Substance ID:
24899567
NACRES:
NA.32

assay

≥95% (HPLC)

storage temp.

−20°C

SMILES string

CC(C)CC(NC(=O)CN(C)C(=O)C(Cc1ccccc1)NC(=O)C(Cc2ccccc2)NC(=O)C(CCC(N)=O)NC(=O)C(CCC(N)=O)NC(=O)C3CCCN3C(=O)C(CCCCN)NC(=O)C4CCCN4C(=O)C(N)CCCNC(N)=N)C(=O)NC(CCS(C)(=O)=O)C(N)=O

InChI

1S/C64H100N18O15S/c1-38(2)34-46(57(89)74-42(54(69)86)28-33-98(4,96)97)73-53(85)37-80(3)62(94)48(36-40-18-9-6-10-19-40)79-58(90)47(35-39-16-7-5-8-17-39)78-56(88)43(24-26-51(67)83)75-55(87)44(25-27-52(68)84)76-59(91)50-23-15-32-82(50)63(95)45(21-11-12-29-65)77-60(92)49-22-14-31-81(49)61(93)41(66)20-13-30-72-64(70)71/h5-10,16-19,38,41-50H,11-15,20-37,65-66H2,1-4H3,(H2,67,83)(H2,68,84)(H2,69,86)(H,73,85)(H,74,89)(H,75,87)(H,76,91)(H,77,92)(H,78,88)(H,79,90)(H4,70,71,72)

InChI key

OUPXSLGGCPUZJJ-UHFFFAOYSA-N

Gene Information

human ... TACR1(6869)
mouse ... TACR1(21336)
rat ... TACR1(24807)

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Amino Acid Sequence

Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Sar-Leu-Met[O]2-NH2

Biochem/physiol Actions

Highly selective NK-1 receptor agonist.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Takayuki Endoh
Brain research, 1110(1), 116-127 (2006-07-29)
Neurokinins, such as substance P (SP), modulate the reflex regulation of cardiovascular and respiratory function in the CNS, particularly in the nucleus tractus solitarius (NTS). There is considerable evidence of the action of SP in the NTS, but the precise
Arvind K Chappa et al.
Pharmaceutical research, 23(6), 1201-1208 (2006-05-27)
Substance P (SP; NH3(+)-Arg(+)-Pro-Lys(+)-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2) belongs to a group of neurokinins that are widely distributed in the central nervous system and peripheral nervous system. The biological effects mediated by SP in the central nervous system include regulation of affective behavior, emesis
Angelina Y Fong et al.
The Journal of physiology, 575(Pt 3), 869-885 (2006-07-11)
In the present study, we examined the role of the neurokinin-1 receptor (NK1R) in the modulation of respiratory rhythm in a functionally identified bradypnoeic region of the ventral respiratory group (VRG) in the in situ arterially perfused juvenile rat preparation.
Qiao-Ling Cui et al.
The European journal of neuroscience, 26(7), 1853-1861 (2007-09-18)
Substance P is a member of the neurokinin family. Previous studies have reported the existence of substance P and its high-affinity receptor, neurokinin-1 receptor, in globus pallidus. Employing in vivo extracellular recording combined with behavioural tests, the effects of substance
Frank Cloutier et al.
British journal of pharmacology, 148(1), 25-38 (2006-02-24)
1 Effects of intrathecally (i.t.) injected tachykinin NK-1 and -3 receptor agonists and antagonists were measured on mean arterial blood pressure (MAP) and heart rate (HR) in awake unrestrained spontaneously hypertensive rats (SHR,15-week-old) and age-matched Wistar Kyoto rats (WKY). Quantitative
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