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N4779

Sigma-Aldrich

5-Nitro-2-(3-phenylpropylamino)benzoic acid

≥98%

Sinónimos:

NPPB

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About This Item

Fórmula empírica (notación de Hill):
C16H16N2O4
Número de CAS:
107254-86-4
Peso molecular:
300.31
MDL number:
MFCD00153851
UNSPSC Code:
12352200
PubChem Substance ID:
24277859
NACRES:
NA.77

assay

≥98%

form

solid

solubility

ethanol: 3 mg/mL
DMSO: 37 mg/mL
H2O: insoluble

storage temp.

−20°C

SMILES string

OC(=O)c1cc(ccc1NCCCc2ccccc2)[N+]([O-])=O

InChI

1S/C16H16N2O4/c19-16(20)14-11-13(18(21)22)8-9-15(14)17-10-4-7-12-5-2-1-3-6-12/h1-3,5-6,8-9,11,17H,4,7,10H2,(H,19,20)

InChI key

WBSMIPAMAXNXFS-UHFFFAOYSA-N

Biochem/physiol Actions

Potent chloride channel blocker.

Features and Benefits

This compound is featured on the Chloride Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Alwin Scharstuhl et al.
PloS one, 4(8), e6688-e6688 (2009-08-21)
We previously identified curcumin as a potent inducer of fibroblast apoptosis, which could be used to treat hypertrophic scar formation. Here we investigated the underlying mechanism of this process. Curcumin-induced apoptosis could not be blocked by caspase-inhibitors and we could
Valia Verrière et al.
PloS one, 7(5), e37746-e37746 (2012-06-05)
Cystic Fibrosis (CF) is a genetic disease characterised by a deficit in epithelial Cl(-) secretion which in the lung leads to airway dehydration and a reduced Airway Surface Liquid (ASL) height. The endogenous lipoxin LXA(4) is a member of the
Tae Sik Sung et al.
The Journal of physiology, 596(9), 1549-1574 (2018-02-13)
Enteric neurotransmission is essential for gastrointestinal (GI) motility, although the cells and conductances responsible for post-junctional responses are controversial. The calcium-activated chloride conductance (CaCC), anoctamin-1 (Ano1), was expressed by intramuscular interstitial cells of Cajal (ICC-IM) in proximal stomach and not
Michael R Bristow et al.
JACC. Basic to translational science, 5(9), 871-883 (2020-08-25)
Using serial analysis of myocardial gene expression employing endomyocardial biopsy starting material in a dilated cardiomyopathy cohort, we show that mRNA expression of the severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) cardiac myocyte receptor ACE2 is up-regulated with remodeling and with reverse
Agnieszka Dyrda et al.
PloS one, 5(2), e9447-e9447 (2010-03-03)
The mechanical, rheological and shape properties of red blood cells are determined by their cortical cytoskeleton, evolutionarily optimized to provide the dynamic deformability required for flow through capillaries much narrower than the cell's diameter. The shear stress induced by such
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