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M5750

Menadione sodium bisulfite

Name: Menadione sodium bisulfite
Brand: SIGMA
Price: 66.4 USD
Availability: InStock

synthetic, ≥95% (TLC), Prothrombogenic compound, powder

Sinónimos:

2-Methyl-1,4-naphthoquinone sodium bisulfite

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Tamaño de envase	Disponibilidad	Precio
25 g	Envío estimado HOYdesdeMILWAUKEE	$66.40
100 g	Comprobar disponibilidad del carrito	$180.00
1 kg	Envío estimado HOYdesdeMILWAUKEE	$895.00

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Fórmula empírica (notación de Hill):

C₁₁H₉NaO₅S

Número CAS:

130-37-0

Peso molecular:

276.24

NACRES:

NA.77

PubChem Substance ID:

24897038

UNSPSC Code:

12352200

EC Number:

204-987-0

MDL number:

MFCD00051456

Assay:

≥95% (TLC)

Form:

powder

$66.40

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Propiedades

Nombre del producto

Menadione sodium bisulfite, ≥95% (TLC)

biological source

synthetic

Quality Segment

200

assay

≥95% (TLC)

form

powder

color

white to off-white

solubility

H₂O: ≥50 mg/mL, clear, colorless to faintly yellow

application(s)

cell analysis

originator

Eli Lilly

storage temp.

−20°C

SMILES string

[Na+].CC1(CC(=O)c2ccccc2C1=O)S([O-])(=O)=O

InChI

1S/C11H10O5S.Na/c1-11(17(14,15)16)6-9(12)7-4-2-3-5-8(7)10(11)13;/h2-5H,6H2,1H3,(H,14,15,16);/q;+1/p-1

InChI key

XDPFHGWVCTXHDX-UHFFFAOYSA-M

Descripción

Application

Menadione sodium bisulfite has been used:

as a priming agent in tomato for improving salt tolerance
to induce reactive oxygen species (ROS) in human lung epithelium BEAS-2B microtissues
to induce endogenous superoxide production in mouse C17.2 neural stem cells

Biochem/physiol Actions

Menadione sodium bisulfite is a water-soluble form of menadione, which belongs to the Vitamin K class of compounds. These are necessary for the biosynthesis of prothrombin and other blood clotting factors. Menadione is a prothrombogenic compound and is used as a model quinone in cell culture and in vivo investigations.

Menadione has been shown to affect gap-junctional intercellular communication by mediation of tyrosine phosphorylation. Menadione has demonstrated cytotoxic activity against a variety of cell lines and can induce apoptosis in cultured cells, such as osteoclasts and osteoblasts, via elevation of peroxide and superoxide radical levels.

An HPLC method for detection of menadione sodium bisulfite in multivitamin formulations has been published. A chemiluminescence assay for menadione sodium bisulfite in pharmaceutical preparations and biological fluids has been reported.

Features and Benefits

This compound was developed by Eli Lilly. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Other Notes

Water soluble vitamin K₃.

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Este artículo	N1786	M3781	SML1662
Sigma-Aldrich M5750 Menadione sodium bisulfite	Sigma-Aldrich N1786 NSC 95397	Sigma-Aldrich M3781 6α-Methylprednisolone 21-hemisuccinate sodium salt	Sigma-Aldrich SML1662 Buparvaquone
form powder	form powder	form lyophilized powder	form powder
assay ≥95% (TLC)	assay ≥97% (HPLC)	assay ≥98.00% (TLC)	assay ≥98% (HPLC)
Quality Level 200	Quality Level 100	Quality Level 100	Quality Level 200
storage temp. −20°C	storage temp. −20°C	storage temp. room temp	storage temp. 2-8°C
solubility H₂O: ≥50 mg/mL, clear, colorless to faintly yellow	solubility DMSO: 16 mg/mL	solubility water: 50 mg/mL, clear, colorless to faintly yellow	solubility DMSO: soluble, chloroform: soluble
originator Eli Lilly	originator -	originator -	originator -