L9045
Lipodisq®
Styrene:Maleic Anhydride Copolymer 3:1
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| Tamaño de envase | SKU | Disponibilidad | Precio |
|---|---|---|---|
| 100 mg | Comprobar disponibilidad del carrito | $346.00 |
Acerca de este artículo
NACRES:
NA.26
UNSPSC Code:
12352202
Form:
powder
Biological source:
synthetic
$346.00
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Servicio técnico
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Permítanos ayudarleGeneral description
Lipodisq® reagents are novel polymers derived from styrene and maleic acid. Lipodisq® polymers are capable of forming nanosized lipid-based discoidal particles capable of incorporating membrane proteins. Lipodisqs typically have a diameter of 9-10 nm at pH 7.4.
Application
Lipodisq® reagents are novel polymers derived from styrene and maleic acid. Lipodisq polymers are capable of forming nanosized lipid-based discoidal particles capable of incorporating membrane proteins. The Lipodisq technology can solubilize commonly used lipids such as dimyristoylphosphatidylcholine (DMPC) without the use of detergents. In general, Lipodisq polymers are potentially useful in mitigating the use of detergents for the solubilization of membrane proteins. Lipodisqs typically have a diameter of 9-10 nm at pH 7.4.
The Lipodisq technology can solubilize commonly used lipids such as dimyristoylphosphatidylcholine (DMPC) without the use of detergents.
Functional pH range: 6.0 - 9.0
Functional pH range: 6.0 - 9.0
Biochem/physiol Actions
Lipodisq® polymers are potentially useful in mitigating the use of detergents for solubilization of membrane proteins. Dissolving this product in an aqueous solution, with sufficient base (e.g. KOH, NaOH), causes hydrolysis of each anhydride moiety into two carboxylic acid/carboxylate groups. This action renders the SMA polymer soluble in aqueous media. Lipodisq® acts as a potential membrane mimic system.
Legal Information
Lipodisq is a registered trademark of Malvern Cosmeceutics Limited
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Este artículo | |||
|---|---|---|---|
| biological source synthetic | biological source synthetic | biological source - | biological source synthetic |
| form powder | form powder | form - | form powder |
| storage temp. room temp | storage temp. room temp | storage temp. room temp | storage temp. room temp |
| Quality Level 200 | Quality Level 200 | Quality Level 200 | Quality Level 200 |
Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Contenido relacionado
Instructions
Detergent-free incorporation of a seven-transmembrane receptor protein into nanosized bilayer Lipodisq particles for functional and biophysical studies
Orwick-Rydmark M, et al.
Nano Letters, 12(9), 4687-4692 (2012)
Characterizing the structure of lipodisq nanoparticles for membrane protein spectroscopic studies
Zhang R, et al.
Biochimica et Biophysica Acta - Biomembranes, 1848(1), 329-333 (2015)
Maria Lyngaas Torgersen et al.
Journal of biomedical nanotechnology, 16(4), 419-431 (2020-09-25)
Many promising pharmaceutically active compounds have low solubility in aqueous environments and their encapsulation into efficient drug delivery vehicles is crucial to increase their bioavailability. Lipodisq nanoparticles are approximately 10 nm in diameter and consist of a circular phospholipid bilayer
Número de artículo de comercio global
| SKU | GTIN |
|---|---|
| L9045-100MG | 04061833234860 |