The molecular weight of human lactoferrin, including recombinant forms expressed in rice, is approximately 80 kDa.
L4040
Lactoferrin human
recombinant, expressed in rice, Partially iron saturated, ≥90% (SDS-PAGE)
Sinónimos:
Growth-inhibiting protein 12, Lactotransferrin, Talalactoferrin
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| Tamaño de envase | SKU | Disponibilidad | Precio |
|---|---|---|---|
| 100 mg | Comprobar disponibilidad del carrito | $202.00 |
Acerca de este artículo
Form:
powder
Assay:
≥70% protein basis (Bradford), ≥90% (SDS-PAGE)
Biological source:
human
Recombinant:
expressed in rice
Servicio técnico
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Biochem/physiol Actions
Lactoferrin is an iron binding protein. It is structurally similar to transferrin, the plasma iron transport protein; but lactoferrin has a much higher affinity for iron (250 fold). It is very abundant in colostrum and small amounts can also be found in tears, saliva, mucous secretions and in the secondary granules of neutrophils. It is made by mucosal epithelium and neutrophils and is released by these cells in response to inflammatory stimuli. Bacterial growth is inhibited by its ability to sequester iron and also permeabilize bacterial cell walls by binding to lipopolysaccharides through its N-terminus. Lactoferrin can inhibit viral infection by binding tightly to the viral envelope protein. This prevents cell-virus fusion by blocking the binding domain. Lactoferrin appears to activate host defense systems in part by stimulating the release of interleukin-8, a neutrophil activator. It may also be involved in antibody and interleukin synthesis, lymphocyte proliferation and complement activation.
Other Notes
rhLactoferrin manufactured in the USA by InVitria.
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Este artículo | |||
|---|---|---|---|
| recombinant expressed in rice | recombinant expressed in rice | recombinant - | recombinant - |
| assay ≥70% protein basis (Bradford), ≥90% (SDS-PAGE) | assay ≥90% (SDS-PAGE), ≥90% (biuret) | assay ≥85% (GE) | assay ~80% (GE) |
| technique(s) microbiological culture: suitable | technique(s) microbiological culture: suitable | technique(s) - | technique(s) - |
| biological source human | biological source human | biological source human milk | biological source human milk |
| form powder | form powder | form solid | form solid |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Chuang Guo et al.
Food & function, 11(8), 7183-7196 (2020-08-07)
Lactoferrin (Lf), an iron-binding glycoprotein, has been shown to possess antioxidant and anti-inflammatory properties and exert modulatory effects on lipid homeostasis and non-alcoholic fatty liver disease (NAFLD), but our understanding of its regulatory mechanisms is limited and inconsistent. We used
P Kragsbjerg et al.
Thorax, 50(12), 1253-1257 (1995-12-01)
The role of cytokines in the pathogenesis of pneumonia is still poorly understood. In a previous study the diagnostic value of measuring blood concentrations of interleukin 6 and interferon gamma was established. In the present study the value of blood
Thuy Nguyen Thi Dao et al.
Journal of extracellular vesicles, 11(2), e12195-e12195 (2022-02-22)
Cancer cell-derived extracellular vesicles (EVs) are promising biomarkers for cancer diagnosis and prognosis. However, the lack of rapid and sensitive isolation techniques to obtain EVs from clinical samples at a sufficiently high yield limits their practicability. Chimeric nanocomposites of lactoferrin
Número de artículo de comercio global
| SKU | GTIN |
|---|---|
| L4040-100MG | 04061833957233 |
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I want to ask what is the size of the protein like how many kDa?. Because I cannot see the SDS page results. Thank you
1 answer-
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Hello, I need to buy this product to evaluate bacteria inhibition under different conditions. As is described in bibliografy, the main antimicrobial peptide is in the N-terminal. Is the N terminal exposed or linek ot His-tag?
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Could you please specify the % of iron saturation in this product?
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The iron content of this material is 0.12%. This information is reported in the lot specific Certificate of Analysis. Please see the link below to review a sample or lot specific Certificate:
https://www.sigmaaldrich.com/US/en/product/sigma/l4040#product-documentationHelpful?
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