I4632
2-Iminobiotin
≥98% (TLC)
Sinónimos:
Guanidinobiotin, Hexahydro-2-imino-1H-thieno[3,4-d]imidazole-4-pentanoic acid
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| Tamaño de envase | SKU | Disponibilidad | Precio |
|---|---|---|---|
| 100 mg | Disponible para enviar HOYdesdeMILWAUKEE | $204.00 |
Acerca de este artículo
Fórmula empírica (notación de Hill):
C10H17N3O2S
Número CAS:
Peso molecular:
243.33
UNSPSC Code:
12352203
NACRES:
NA.46
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
18952
Servicio técnico
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Permítanos ayudarlebiological source
synthetic (organic)
Quality Level
assay
≥98% (TLC)
form
powder
solubility
1 M HCl: 50 mg/mL, clear, colorless
storage temp.
2-8°C
SMILES string
[H][C@]12CS[C@@H](CCCCC(O)=O)[C@@]1([H])NC(=N)N2
InChI
1S/C10H17N3O2S/c11-10-12-6-5-16-7(9(6)13-10)3-1-2-4-8(14)15/h6-7,9H,1-5H2,(H,14,15)(H3,11,12,13)/t6-,7-,9-/m0/s1
InChI key
WWVANQJRLPIHNS-ZKWXMUAHSA-N
General description
2-Iminobiotin is a cyclic guanidino analog of biotin that has high affinity for avidin at high pH (>9) and low affinity at low pH (<6). The proteins that are iminobiotinylated are selectively contained within the avidin column at pH 9 to 11 and may be eluted at pH 4 or by the addition of biotin. This technique may be very useful in the study of cell surface proteins by labeling and selectively recovering the components that are periodate-sensitive from intact human erythrocyte surface.[1] 2-Iminobiotin reversibly inhibits NOS (nitric oxide synthases) via its guanidino group. It inhibits NO biosynthesis and may be important to understand the binding-site interactions for this important class of enzymes. NOS oxidizes the guanidino-nitrogen of L-arginine to produce nitric oxide and L-citrulline.[2]
Application
2-Iminobiotin has been used as a competitive inhibitor to bind to biotic binding sites on streptavidin in order to restore fluorescence signal.[3]
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Este artículo | |||
|---|---|---|---|
| assay ≥98% (TLC) | assay ≥98% (HPLC) | assay ≥97% (HPLC) | assay ≥97% (mixture of regioisomers, HPLC) |
| biological source synthetic (organic) | biological source - | biological source - | biological source - |
| Quality Level 200 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| form powder | form powder | form powder | form solid |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
| solubility 1 M HCl: 50 mg/mL, clear, colorless | solubility DMSO: 2 mg/mL, clear | solubility DMSO: 100 mg/mL | solubility DMSO: 25 mg/mL, water: 50 mg/mL |
Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Tijen Utkan et al.
Pharmacology, biochemistry, and behavior, 101(4), 515-519 (2012-03-13)
The aim of this study was to compare the effects of both neuronal NOS (nNOS) and inducible NOS (iNOS) inhibitor 2-iminobiotin, with the more selective nNOS inhibitor N(ω)-propyl-L-arginine (NPLA) and selective inducible NOS (iNOS) inhibitor aminoguanidine, on emotional learning, working
Katsuhiko Sato et al.
Journal of colloid and interface science, 315(1), 396-399 (2007-07-17)
The effects of hydrogen peroxide on the electrochemical decomposition of layer-by-layer thin films composed of 2-iminobiotin-labeled poly(ethyleneimine) (ib-PEI) and avidin were studied. An ib-PEI/avidin thin film prepared on the surface of a platinum (Pt) film-coated quartz resonator was electrochemically decomposed
F K Athappilly et al.
Protein science : a publication of the Protein Society, 6(6), 1338-1342 (1997-06-01)
Streptavidin binds 2'-iminobiotin in a pH-dependent fashion--affinity decreases as the pH is lowered. This property makes the purification of compounds conjugated to streptavidin or immobiotin possible under mild conditions by affinity chromatography. In order to understand the molecular details of
Número de artículo de comercio global
| SKU | GTIN |
|---|---|
| I4632-100MG | 04061833262528 |