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G8296

GRK5, active, GST tagged human

PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Sinónimos:

GPRK5

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Tamaño de envaseSKUDisponibilidadPrecio
10 μg
Comprobar disponibilidad del carrito
$489.00

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NACRES:
NA.32
UNSPSC Code:
12352200
Specific activity:
32-44 nmol/min·mg
Assay:
≥70% (SDS-PAGE)
Recombinant:
expressed in baculovirus infected Sf9 cells

$489.00

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recombinant

expressed in baculovirus infected Sf9 cells

Quality Level

200

product line

PRECISIO® Kinase

assay

≥70% (SDS-PAGE)

form

buffered aqueous glycerol solution

specific activity

32-44 nmol/min·mg

mol wt

~95 kDa

UniProt accession no.

P34947

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... GRK5(2869)

General description

GRK5 (G protein-coupled receptor kinase 5) belongs to the G-protein coupled receptor kinase family, and shows major expression in normal human heart. This protein contains a nuclear localization sequence and hence localizes in nucleus.[1][2]

Biochem/physiol Actions

GRK5 (G protein-coupled receptor kinase 5) controls the functions of catecholamines, which bind and activate β-adrenergic receptors, and have cardiac inotropic and chronotropic actions. It is responsible for the uncoupling from G protein by facilitating β1-adrenergic receptor phosphorylation and β-arrestin recruitment.[1] This protein plays a key role in growth and metastasis in prostate cancer, where it phosphorylates moesin.† A genome-wide association study (GWAS) has shown that rs10886471 variant in GRK5 gene is linked with susceptibility to type 2 diabetes mellitus (T2DM).[3]

Physical form

Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.

Legal Information

PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany

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Este artículo
SRP5322SRP5034SRP5035
GRK5, active, GST tagged human PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Sigma-Aldrich

G8296

GRK5, active, GST tagged human

GRK3, active, GST tagged human PRECISIO®, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Sigma-Aldrich

SRP5322

GRK3, active, GST tagged human

GRK2, active, GST tagged human PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Sigma-Aldrich

SRP5034

GRK2, active, GST tagged human

GRK6, active, GST tagged human PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Sigma-Aldrich

SRP5035

GRK6, active, GST tagged human

Gene Information

human ... GRK5(2869)

Gene Information

human ... ADRBK2(157)

Gene Information

human ... ADRBK1(156)

Gene Information

human ... GRK6(2870)

specific activity

32-44 nmol/min·mg

specific activity

4.8-7.2 nmol/min·mg

specific activity

4.5-6.1 nmol/min·mg

specific activity

9.4-12.6 nmol/min·mg

assay

≥70% (SDS-PAGE)

assay

≥70% (SDS-PAGE)

assay

≥70% (SDS-PAGE)

assay

≥70% (SDS-PAGE)

form

buffered aqueous glycerol solution

form

buffered aqueous glycerol solution

form

buffered aqueous glycerol solution

form

buffered aqueous glycerol solution

recombinant

expressed in baculovirus infected Sf9 cells

recombinant

expressed in baculovirus infected Sf9 cells

recombinant

expressed in baculovirus infected Sf9 cells

recombinant

expressed in baculovirus infected Sf9 cells

mol wt

~95 kDa

mol wt

~84 kDa

mol wt

~102 kDa

mol wt

~93 kDa

Clase de almacenamiento

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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Certificados de análisis (COA)

Lot/Batch Number
SLBL8134V
SLBK1071V
SLBH0042V
SLBH1086V
SLBG1921V

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Prabir Kumar Chakraborty et al.
Cancer research, 74(13), 3489-3500 (2014-04-24)
G protein-coupled receptor kinases (GRK) regulate diverse cellular functions ranging from metabolism to growth and locomotion. Here, we report an important contributory role for GRK5 in human prostate cancer. Inhibition of GRK5 kinase activity attenuated the migration and invasion of
Zhenfang Xia et al.
PloS one, 9(3), e90597-e90597 (2014-03-07)
A genome-wide association study had showed G-protein-coupled receptor kinase 5 (GRK5) rs10886471 was related to the risk of type 2 diabetes mellitus (T2DM) through upregulated GRK5 mRNA expression. Rs10886471 is located in the intron region of GRK5. However, the mechanism
Miklos D Kertai et al.
Circulation. Cardiovascular genetics, 7(5), 625-633 (2014-07-23)
We hypothesized that genetic variations in the adrenergic signaling pathway and cytochrome P450 2D6 enzyme are associated with new-onset atrial fibrillation (AF) in patients who underwent coronary artery bypass grafting and were treated with perioperative β-blockers (BBs). Two cohorts of
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SKUGTIN
G8296-10UG04061832850313

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