Documentos clave

Ver Toda la documentación

Saltar a

E7280

Elafin

Name: Elafin
Brand: SIGMA
Price: 850 USD

recombinant, expressed in Saccharomyces cerevisiae, powder, >90% (by MS, HPLC and SDS-PAGE),

Sinónimos:

Elastase-specific inhibitor, skin-derived antileukoprotease

Iniciar sesión para ver los precios por organización y contrato.

Seleccione un Tamaño

Cambiar Vistas

Tamaño de envase	SKU	Disponibilidad	Precio
100 μg		Comprobar disponibilidad del carrito	$850.00

Acerca de este artículo

UNSPSC Code:

12352202

NACRES:

NA.77

MDL number:

MFCD00146824

$850.00

Comprobar disponibilidad del carrito

Servicio técnico

¿Necesita ayuda? Nuestro equipo de científicos experimentados está aquí para ayudarle.

Permítanos ayudarle

Propiedades

Nombre del producto

Elafin human, >90% (by MS, HPLC and SDS-PAGE), recombinant, expressed in Saccharomyces cerevisiae

Quality Level

200

recombinant

expressed in Saccharomyces cerevisiae

assay

>90% (by MS, HPLC and SDS-PAGE)

form

powder

potency

1.7 x 10-10 M K_i (human leukocyte elastase), 4.2 x 10-10 M K_i (human proteinase 3)

mol wt

~6 kDa

UniProt accession no.

P19957

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria

mode of action

enzyme | inhibits

shipped in

ambient

storage temp.

−20°C

Gene Information

human ... PI3(5266)

Descripción

General description

Chemical structure: peptide

Biochem/physiol Actions

Exhibits co-existent antimicrobial and antiproteolytic activities.1 Inhibits WAP-type four-disulfide core (WFDC) domain containing elastases. Antimicrobial spectrum: Gram-positive and Gram-negative bacteria.

Inhibitor of human leukocyte elastase and proteinase 3, originally isolated from the skin of patients with psoriasis. May protect against certain autoimmune tissue damage.

Inhibitor of human leukocyte elastase and proteinase 3, originally isolated from the skin of patients with psoriasis. May protect against certain autoimmune tissue damage. An elastase inhibitor which is an active fragment of elafin, as well as elafin itself, can also be found in bronchial carcinoma secretions.

Comparar elementos similares

Ver comparación completa

Mostrar Diferencias

1 of 1

Este artículo	94261	A6671	M7152
Sigma-Aldrich E7280 Elafin human	Sigma-Aldrich 94261 LL-37 (human) trifluoroacetate salt	Sigma-Aldrich A6671 Actinonin	Sigma-Aldrich M7152 Magainin I
assay >90% (by MS, HPLC and SDS-PAGE)	assay ≥95% (HPLC)	assay ≥98% (TLC)	assay ≥97% (HPLC)
Gene Information human ... PI3(5266)	Gene Information -	Gene Information human ... ANPEP(290), DPP4(1803), ECE1(1889), LAP3(51056)	Gene Information -
Quality Level 200	Quality Level 200	Quality Level 200	Quality Level 200
form powder	form powder (Lyophilisate)	form powder	form -
storage temp. −20°C	storage temp. −20°C	storage temp. −20°C	storage temp. −20°C
shipped in ambient	shipped in -	shipped in -	shipped in -

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Elija entre una de las versiones más recientes:

Certificados de análisis (COA)

Lot/Batch Number

0000560358

0000519386

0000269791

¿No ve la versión correcta?

Si necesita una versión concreta, puede buscar un certificado específico por el número de lote.

Busque por un COA

¿Ya tiene este producto?

Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.

Visite la Librería de documentos

Artículos

Elastase Function and Importance

Elastase application index for understanding leukocyte elastase, a 29KDa serine endoprotease.

Contenido relacionado

Data Sheet - E7280

Datasheet

Human Neutrophil Elastase Proteolytic Activity in Ulcerative Colitis Favors the Loss of Function of Therapeutic Monoclonal Antibodies.

Renata Curciarello et al.

Journal of inflammation research, 13, 233-243 (2020-06-18)

Proteases play an essential role in the pathophysiology of inflammatory bowel disease (IBD), contributing to the intestinal mucosal lesions through the degradation of the extracellular matrix and alteration of the barrier function. Ulcerative colitis (UC) is characterized by an extensive

Quantitative analysis of protease recognition by inhibitors in plasma using microscale thermophoresis.

T Dau et al.

Scientific reports, 6, 35413-35413 (2016-10-16)

High abundance proteins like protease inhibitors of plasma display a multitude of interactions in natural environments. Quantitative analysis of such interactions in vivo is essential to study diseases, but have not been forthcoming, as most methods cannot be directly applied

Neutrophil elastase triggers the development of autoimmune diabetes by exacerbating innate immune responses in pancreatic islets of non-obese diabetic mice.

Lingling Shu et al.

Clinical science (London, England : 1979), 134(13), 1679-1696 (2020-07-08)

Type 1 diabetes is an autoimmune disease resulted from self-destruction of insulin-producing pancreatic β cells. However, the pathological pathways that trigger the autoimmune destruction remain poorly understood. Clinical studies have demonstrated close associations of neutrophils and neutrophil elastase (NE) with

Ver todos los artículos relacionados

Número de artículo de comercio global

SKU	GTIN
E7280-100UG	04061833605035

Questions

Reviews

No rating value