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E3531

Evodiamine

Name: Evodiamine
Brand: SIGMA

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Acerca de este artículo

Fórmula empírica (notación de Hill):

C₁₉H₁₇N₃O

Número CAS:

518-17-2

Peso molecular:

303.36

NACRES:

NA.25

PubChem Substance ID:

329799050

UNSPSC Code:

12352116

MDL number:

MFCD06407824

Este producto está descatalogado. Póngase en contacto con el Servicio técnicopara asistencia

Propiedades

application(s)

metabolomics
vitamins, nutraceuticals, and natural products

storage temp.

2-8°C

SMILES string

[H][C@@]1(N(C)C2=C3C=CC=C2)C4=C(C(C=CC=C5)=C5N4)CCN1C3=O

InChI

1S/C19H17N3O/c1-21-16-9-5-3-7-14(16)19(23)22-11-10-13-12-6-2-4-8-15(12)20-17(13)18(21)22/h2-9,18,20H,10-11H2,1H3/t18-/m0/s1

InChI key

TXDUTHBFYKGSAH-SFHVURJKSA-N

Descripción

Biochem/physiol Actions

Evodiamine is an indole alkaloid found in Evodia rutaescarpa. It acts as an anti-inflammatory compound; the mechanism of action may be inhibition of prostaglandin E₂ synthesis or by cyclooxygenase 2 induction and NF-κB activation. Evodiamine has been studied for multiple cellular effects, including apoptotic activity, interference with metastasis and inhibition of angiogenesis.

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Este artículo	P3869	616454	572630
Sigma-Aldrich E3531 Evodiamine	Supelco P3869 Phosphorus standard solution	Sigma-Aldrich 616454 TGF-β RI Kinase Inhibitor IV	Sigma-Aldrich 572630 SU5402
application(s) metabolomics vitamins, nutraceuticals, and natural products	application(s) -	application(s) -	application(s) -
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C

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pictograms

GHS07

signalword

Warning

hcodes

H302

pcodes

P301 + P312 + P330

Hazard Classifications

Acute Tox. 4 Oral

Clase de almacenamiento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

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Artículos

NF-κB and Inflammation

Chronic inflammation is an underlying factor in the development and progression of many of the chronic diseases of aging, such as arthritis, atherosclerosis, diabetes, and cancer.

Effects of Evodiamine on the Pharmacokinetics of Dapoxetine and Its Metabolite Desmethyl Dapoxetine in Rats.

Rui-fang Li et al.

Pharmacology, 97(1-2), 43-47 (2015-11-21)

The objective of this work was to investigate the effect of orally administered evodiamine on the pharmacokinetics of dapoxetine and its active metabolite desmethyl dapoxetine in rats. Twelve healthy male Sprague-Dawley rats were randomly divided into 2 groups: the control

A mediator of phosphorylated Smad2/3, evodiamine, in the reversion of TAF-induced EMT in normal colonic epithelial cells.

Wanbin Yang et al.

Investigational new drugs, 37(5), 865-875 (2018-11-30)

Purpose Transdifferentiation exists within stromal cells in the tumour microenvironment. Transforming growth factor-β (TGF-β) secreted by tumour-associated fibroblasts (TAFs) affects the differentiation states of epithelial cells, including epithelial-mesenchymal transition (EMT). Evodiamine, a natural drug, can regulate differentiation. However, the specific

Anti-tumor effect of evodiamine by inducing Akt-mediated apoptosis in hepatocellular carcinoma.

Fan Yang et al.

Biochemical and biophysical research communications, 485(1), 54-61 (2017-02-13)

Evodiamine is an alkaloid extracted from Euodia rutaecarpa (Juss.) Benth. There is little information about the mechanisms of evodiamine on the apoptosis of hepatocellular carcinoma (HCC). A xenograft model and CCK8 assay were used to investigate the anti-HCC effect of

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Número de artículo de comercio global

SKU	GTIN
E3531-250MG	04061832407975

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