The chemicals encyclopedia published by the Royal Society of Chemistry (11th ed., entry #2939) reports a melting point of 217-218°C.
D9302
Diacerein
≥95% (HPLC)
Sinónimos:
1,8-Diacetoxy-3-carboxyanthraquinone
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Acerca de este artículo
Fórmula empírica (notación de Hill):
C19H12O8
Número CAS:
Peso molecular:
368.29
NACRES:
NA.25
PubChem Substance ID:
UNSPSC Code:
41116107
EC Number:
237-310-2
MDL number:
Assay:
≥95% (HPLC)
Form:
powder
assay
≥95% (HPLC)
form
powder
SMILES string
CC(=O)Oc1cccc2C(=O)c3cc(cc(OC(C)=O)c3C(=O)c12)C(O)=O
InChI
1S/C19H12O8/c1-8(20)26-13-5-3-4-11-15(13)18(23)16-12(17(11)22)6-10(19(24)25)7-14(16)27-9(2)21/h3-7H,1-2H3,(H,24,25)
InChI key
TYNLGDBUJLVSMA-UHFFFAOYSA-N
Biochem/physiol Actions
Diacerin is an inhibitor of Interleukin-1B (IL-1B) production.
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| assay ≥95% (HPLC) | assay - | assay ≥96.5% (GC), 97% | assay - |
| form powder | form solid | form liquid | form - |
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Pascal Richette
La Revue du praticien, 62(5), 654-660 (2012-06-27)
According to the European League of Associations of Rheumatology (EULAR) and the American College of Rheumatology (ACR), acetaminophen should be used as a first-line therapy in patients with osteoarthritis, because of its safety and effectiveness. NSAID should be considered in
Umut Kalyoncu et al.
Joint, bone, spine : revue du rhumatisme, 76(4), 389-393 (2009-02-17)
The objective of the present study was to assess the frequency of self-reported psoriasis in a hip osteoarthritis (OA) cohort, and a secondary objective was to assess the course of hip OA with psoriasis. ECHODIAH was a 3-year, randomised double-blind
Achint Jain et al.
Journal of biomedical nanotechnology, 9(5), 891-900 (2013-06-28)
Osteoarthritis is the most common, multi component joint disease mainly characterized by destruction of articular cartilage which leads up to subchondral bone. Current treatment by NSAID's gives only symptomatic relief but semi-synthetic anthraquinone diacerein is novel chondroprotective agent intended for
Número de artículo de comercio global
| SKU | GTIN |
|---|---|
| D9302-50MG | 04061833590591 |
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What is the melting point of Product D9302, Diacerein?
1 answer-
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Can Product D9302, Diacerein, be dissolved in DMSO?
1 answer-
Yes. Diacerein is soluble in DMSO at 1 mg/mL. The compound is also soluble in acetic acid at a concentration of 25 mg in 8 mL, as stated on the specification sheet.
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What is the biological activity of Product D9302, Diacerein?
1 answer-
Martindale, 30th ed. indicates that "Diacerein is a non-steroidal anti-inflammatory agent that has been used in musculoskeletal and joint disorders." Diacerein acts by inhibiting interleukin-1. The chemicals encyclopedia published by the Royal Society of Chemistry, 11th ed., indicates that Diacerein "demonstrates anti-arthritic activity without inhibiting prostaglandin synthesis".
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What is the Department of Transportation shipping information for this product?
1 answer-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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What is the mechanism of action of Product D9302, Diacerein?
1 answer-
"Diacerein is a slow acting symptomatic treatment of osteoarthritis which has demonstrated efficacy on functional manifestations of osteoarthritis and on the structural component. Two mechanisms of action have been validated: in vitro inhibition of interleukin-1 (IL-1) synthesis, the main cytokine involved in cartilage destruction, and activity on the synthesis of proteoglycans, and hyaluronic acid, the principal component of cartilage. Other studies presented here have provided further details concerning other mechanisms of action of diacerein", according to Presse Med., 33(9 Pt 2), S10-S12 (2004).
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