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D6140
Demeclocycline hydrochloride
powder or crystals, suitable for cell culture
Sinónimos:
7-Chloro-6-demethyltetracycline hydrochloride, Demethylchlorotetracycline hydrochloride
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| Tamaño de envase | SKU | Disponibilidad | Precio |
|---|---|---|---|
| 1 g | Disponible para enviar HOYdesdeMILWAUKEE | $281.00 |
Acerca de este artículo
Fórmula empírica (notación de Hill):
C21H21ClN2O8 · HCl
Número CAS:
Peso molecular:
501.31
NACRES:
NA.75
PubChem Substance ID:
UNSPSC Code:
12352207
EC Number:
200-592-2
MDL number:
Beilstein/REAXYS Number:
3849198
Servicio técnico
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Permítanos ayudarleNombre del producto
Demeclocycline hydrochloride, powder or crystals
assay
89.5-102.0% anhydrous basis
Quality Level
form
powder or crystals
technique(s)
cell culture | mammalian: suitable
solubility
soluble (1 mg/mL of Demeclocycline Hydrochloride in 0.01 N hydrochloric acid)
antibiotic activity spectrum
Gram-negative bacteria, Gram-positive bacteria
mode of action
protein synthesis | interferes
storage temp.
−20°C
SMILES string
Cl[H].[H][C@]12C[C@@]3([H])[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]3(O)C(O)=C1C(=O)c4c(O)ccc(Cl)c4[C@H]2O
InChI
1S/C21H21ClN2O8.ClH/c1-24(2)14-7-5-6-10(16(27)12-9(25)4-3-8(22)11(12)15(6)26)18(29)21(7,32)19(30)13(17(14)28)20(23)31;/h3-4,6-7,14-15,25-26,28-29,32H,5H2,1-2H3,(H2,23,31);1H/t6-,7-,14-,15-,21-;/m0./s1
InChI key
GVSJQNRGSCOSNJ-KBHRXELFSA-N
General description
Chemical structure: tetracycline
Biochem/physiol Actions
Because it is excreted more slowly than tetracycline, it maintains effective blood levels for longer periods of time.
Demeclocycline hydrochloride is a tetracycline antibiotic derived from a strain of Streptomyces aureofaciens. DMC protects neurons from glutamate induced toxicity by suppressing calpain I and II activities.
Used to study mechanisms of bacterial protein synthesis inhibition at the level of the 30S subunit and aminoacy-tRNA A-site binding.
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Este artículo | |||
|---|---|---|---|
| mode of action protein synthesis | interferes | mode of action - | mode of action - | mode of action - |
| antibiotic activity spectrum Gram-negative bacteria, Gram-positive bacteria | antibiotic activity spectrum - | antibiotic activity spectrum - | antibiotic activity spectrum - |
| technique(s) cell culture | mammalian: suitable | technique(s) - | technique(s) HPLC: suitable, gas chromatography (GC): suitable | technique(s) - |
| Quality Level 200 | Quality Level - | Quality Level 300 | Quality Level - |
| form powder or crystals | form solid | form - | form - |
| assay 89.5-102.0% anhydrous basis | assay - | assay - | assay - |
signalword
Warning
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Muta. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
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Our laboratories have used genetically engineered mouse models (GEMMs) to assess genetic contributions to skeletal diseases such as osteoporosis and osteoarthritis. Studies on the genetic contributions to OA are often done by assessing how GEMMs respond to surgical methods that
Número de artículo de comercio global
| SKU | GTIN |
|---|---|
| D6140-1G | 04061833587317 |
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How does the storage temperature relate to shipping conditions?
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The storage conditions that a Sigma-Aldrich catalog and label recommend for products are deliberately conservative. For many products, long-term storage at low temperatures will increase the time during which they are expected to remain in specification and therefore are labeled accordingly. Where short-term storage, shipping time frame, or exposure to conditions other than those recommended for long-term storage will not affect product quality, Sigma-Aldrich will ship at ambient temperature. The products sensitive to short-term exposure to conditions other than their recommended long-term storage are shipped on wet or dry ice. Ambient temperature shipping helps to control shipping costs for our customers. At any time, our customers can request wet- or dry-ice shipment, but the special handling is at customer expense if our product history indicates that the product is stable for regular shipment.
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What is the solubility of Product D6140, Demeclocycline hydrochloride?
1 answer-
Product D6140, Demeclocycline hydrochloride, has been found to be soluble in water at 20mg/ml, with heat as needed. This will yield a clear yellow to very dark green-yellow solution.
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