D144
DALDA
>96%, solid
Sinónimos:
[D-Arg2, Lys4]-Dermorphin-(1-4)-amide
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About This Item
Fórmula empírica (notación de Hill):
C30H44N8O6
Número de CAS:
Peso molecular:
612.72
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
assay
>96%
form
solid
color
white
storage temp.
−20°C
SMILES string
NCCCCC(NC(=O)C(Cc1ccccc1)NC(=O)C(CCCNC(N)=N)NC(=O)C(N)Cc2ccc(O)cc2)C(N)=O
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Amino Acid Sequence
Tyr-D-Arg-Phe-Lys-NH2
Biochem/physiol Actions
Highly selective μ opioid receptor agonist.
Storage Class
8B - Non-combustible corrosive hazardous materials
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Damien J Keating et al.
The Journal of physiology, 555(Pt 2), 489-502 (2004-01-16)
Before the preganglionic regulation of the adrenal medulla is established, hypoxia acts directly on the chromaffin cells to evoke the secretion of catecholamines. This direct action of hypoxia is suppressed by the gradual development of the preganglionic innervation and we
Guo-Min Zhao et al.
The Journal of pharmacology and experimental therapeutics, 302(1), 188-196 (2002-06-18)
Recent studies suggest that delta-opioid receptors play a role in the development of opioid tolerance and led us to hypothesize that highly selective mu-opioid agonists may produce less tolerance. H-2',6'-dimethyltyrosine-D-Arg-Phe-Lys-NH(2) ([Dmt(1)]DALDA) has extraordinary selectivity for mu-receptors (K(i)(delta)/K(i)(mu) > 14,000). Daily
Yong Ben et al.
British journal of pharmacology, 143(8), 987-993 (2004-11-24)
Previously, we reported that H-2',6'-dimethyltyrosine [Dmt(1)]-d-Arg-Phe-Lys-NH(2) (DALDA), an analogue of the naturally occurring opioid peptide dermorphin, is a highly potent and selective mu receptor agonist with low cross-tolerance to morphine. In the present study, we investigated the effect of treating
Haibao Wan et al.
Rapid communications in mass spectrometry : RCM, 17(6), 538-546 (2003-03-07)
The synthetic peptide [Dmt(1)]DALDA (Dmt-D-Arg-Phe-Lys-NH(2); Dmt = 2',6'-dimethyltyrosine; 'super-DALDA') is a mu opioid-receptor agonist. On-line liquid chromatography/quadrupole time-of-flight mass spectrometry and the corresponding stable isotope-incorporated synthetic peptide internal standard were used to quantify [Dmt(1)]DALDA that had been extracted from ovine
Pal Riba et al.
Current medicinal chemistry, 9(1), 31-39 (2002-02-28)
The clinical effectiveness of morphine is limited by several side effects, including the development of tolerance and dependence. Most of these side effects are believed to be mediated by central opioid receptors; therefore, hydrophilic opioids, which don't cross the blood-brain
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