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B8041

Biglycan from bovine articular cartilage

essentially salt-free, lyophilized powder

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Tamaño de envaseSKUDisponibilidadPrecio
0.5 mg
Comprobar disponibilidad del carrito
$1,180.00

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UNSPSC Code:
12352202
NACRES:
NA.75
MDL number:
MFCD00676525
Form:
essentially salt-free, lyophilized powder
Biological source:
bovine articular cartilage
Mol wt:
200-350 kDa

$1,180.00

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biological source

bovine articular cartilage

Quality Level

200

form

essentially salt-free, lyophilized powder

mol wt

200-350 kDa

packaging

glass bottle of 0.5 mg

technique(s)

cell culture | mammalian: suitable

solubility

water: soluble ≥2.00 mg/mL, clear, colorless

UniProt accession no.

P21809

shipped in

dry ice

storage temp.

−20°C

Gene Information

cow ... BGN(280733)

General description

proteoglycan consisting of a 45 kDa core protein and two chrondroitin/dermatan sulfate glycosaminoglycan chains

Biochem/physiol Actions

Biglycan interacts with collagen type I and II, fibronectin and TGF-β. In a low ionic strength (less than 3 mM phosphate) buffer, Biglycan binds more strongly to collagen type I. At higher ionic strengths, Biglycan will instead increase the inhibition effect of TGF-β on osteoclast proliferation at a concentration of 4-20 mg/mL. It also functions to prevent the attachment of CHO cells to fibronectin, with a 50% inhibition at 17-21 mg/mL. As an extracellular component, Biglycan binds TGF-β 1, facilitates bone mineralization and supports osteoblast differentiation thru BMP-4 binding.

Preparation Note

This product is extracted from articular cartilage, chematographically purified, dialyzed against water, and 0.2 μm filtered prior to lyophilization. Once lyophilized, this powder is essentially salt-free. The product is soluble in water at 2 mg/mL.

Other Notes

Biglycan is a 200-350 kDa proteoglycan consisting of a 45 kDa core protein and two chondroitin/dermatan sulfate glycosaminoglycan chains.

Disclaimer

Store this product at -20°C. Stored as supplied, this powder shows little decomposition in 3 years when stored properly.

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Este artículo
A1960D8428T1143
Biglycan from bovine articular cartilage essentially salt-free, lyophilized powder

Sigma-Aldrich

B8041

Biglycan from bovine articular cartilage

Aggrecan from bovine articular cartilage lyophilized powder

Sigma-Aldrich

A1960

Aggrecan from bovine articular cartilage

Decorin from bovine articular cartilage salt-free, lyophilized powder

Sigma-Aldrich

D8428

Decorin from bovine articular cartilage

Trypsinogen from bovine pancreas essentially salt-free, lyophilized powder, ≥10,000 BAEE units/mg protein (E1%/280, after activation to trypsin)

Sigma-Aldrich

T1143

Trypsinogen from bovine pancreas

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

mass spectrometry (MS): suitable

biological source

bovine articular cartilage

biological source

bovine articular cartilage

biological source

bovine articular cartilage

biological source

bovine pancreas

mol wt

200-350 kDa

mol wt

-

mol wt

~100 kDa

mol wt

23,981 Da by calculation

form

essentially salt-free, lyophilized powder

form

lyophilized powder

form

salt-free, lyophilized powder

form

essentially salt-free, lyophilized powder

Gene Information

cow ... BGN(280733)

Gene Information

cow ... AGC1(280985)

Gene Information

cow ... DCN(280760)

Gene Information

bovine ... TRYP8(282603)

solubility

water: soluble ≥2.00 mg/mL, clear, colorless

solubility

H2O: 2 mg/mL

solubility

PBS: ≥2.00 mg/mL, clear, colorless to yellow

solubility

H2O: soluble 10 mg/mL

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificados de análisis (COA)

Lot/Batch Number
0000147615
0000147615
0000089954
11190218
057M4103V

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Contenido relacionado

G Pogány et al.
Archives of biochemistry and biophysics, 313(1), 102-111 (1994-08-15)
Binding of proteoglycans to type I collagen in vitro was assessed using radiolabeled decorin, biglycan, and large proteoglycans and acid-extracted bovine tendon collagen. Decorin, biglycan, and large proteoglycans were all bound to collagen fibrils in phosphate-buffered saline (PBS) containing 3
P J Roughley et al.
Matrix biology : journal of the International Society for Matrix Biology, 14(1), 51-59 (1994-01-01)
In chondrocytes isolated directly from human articular cartilage, without subsequent culture, biglycan mRNA levels decreased with the age of the donor, whereas those for decorin increased. In cultured chondrocytes in the presence of FCS, mRNA levels for biglycan remained similar
Mauricio Moreno et al.
The EMBO journal, 24(7), 1397-1405 (2005-03-19)
The BMP4 signaling pathway plays key roles during early embryonic development and for maintenance of adult homeostasis. In the extracellular space, BMP4 activity is regulated by a group of interacting molecules including the BMP antagonist Chordin, the metalloproteinase Tolloid and
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SKUGTIN
B8041-.5MG04061833442425

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