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B5258

N6-Benzoyladenine

≥99%, powder

Sinónimos:

6-(Benzoylamino)purine, 6-Benzamidopurine, 6-Benzoyladenine, n6-benzoyl adenosine

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Tamaño de envaseSKUDisponibilidadPrecio
5 g

Disponible para enviar HOYdesdeMILWAUKEE

$395.00
$335.75
25 g

Disponible para enviar HOYdesdeMILWAUKEE

$1,590.00

Acerca de este artículo

Fórmula empírica (notación de Hill):
C12H9N5O
Número CAS:
4005-49-6
Peso molecular:
239.23
UNSPSC Code:
41106305
PubChem Substance ID:
24891827
NACRES:
NA.51
MDL number:
MFCD00037927
Assay:
≥99%
Form:
powder
Solubility:
warm ethanol: 10 mg/mL, clear to slightly hazy, colorless to faintly yellow
Storage temp.:
2-8°C

$335.75

Precio de catálogo$395.00Ahorre 15 %
Promoción solo por Internet

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Nombre del producto

N6-Benzoyladenine, ≥99%

Quality Level

200

assay

≥99%

form

powder

solubility

warm ethanol: 10 mg/mL, clear to slightly hazy, colorless to faintly yellow

storage temp.

2-8°C

SMILES string

O=C(Nc1ncnc2nc[nH]c12)c3ccccc3

InChI

1S/C12H9N5O/c18-12(8-4-2-1-3-5-8)17-11-9-10(14-6-13-9)15-7-16-11/h1-7H,(H2,13,14,15,16,17,18)

InChI key

QQJXZVKXNSFHRI-UHFFFAOYSA-N

Application

N6-Benzoyladenine is used in the organic synthesis of adenine derivative molecules such as bicyclic adenine nucleoside via a condensation reaction between L-threo-pentofuranose derivative 1 and 6-N-benzoyladenine and to produce oxy-peptide nucleic acids.

Biochem/physiol Actions

N6-Benzoyladenine comprises of adenine moiety and is a potent inhibitor of bromodomain-containing protein 4 (BRD4). N6-Benzoyladenine modulates tumor necrosis factor α (TNF-α) levels. It elicits cytotoxicity in liver and ileum cancer cells and may serve as a potential candidate agent for cancer chemotherapy.

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1 of 1

Este artículo
B4750B6506SML1967
N6-Benzoyladenine ≥99%

Sigma-Aldrich

B5258

N6-Benzoyladenine

Nα-Benzoyl-DL-arginine β-naphthylamide hydrochloride trypsin substrate

Sigma-Aldrich

B4750

Nα-Benzoyl-DL-arginine β-naphthylamide hydrochloride

Benzamidine hydrochloride hydrate ≥99%

Sigma-Aldrich

B6506

Benzamidine hydrochloride hydrate

N6-(4-Hydroxybenzyl) adenine riboside ≥98% (HPLC)

Sigma-Aldrich

SML1967

N6-(4-Hydroxybenzyl) adenine riboside

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

100

assay

≥99%

assay

≥98% (TLC)

assay

≥99%

assay

≥98% (HPLC)

form

powder

form

powder

form

powder

form

powder

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

warm ethanol: 10 mg/mL, clear to slightly hazy, colorless to faintly yellow

solubility

DMF: 50 mg/mL, clear, colorless to faintly yellow

solubility

water: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow

solubility

DMSO: 2 mg/mL, clear

pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Repr. 2 - Skin Sens. 1

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certificados de análisis (COA)

Lot/Batch Number
0000557478
0000555338
0000525401
0000557478
0000555338

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Visite la Librería de documentos

Structure-Activity Relationship Study of N6-Benzoyladenine-Type BRD4 Inhibitors and Their Effects on Cell Differentiation and TNF-alpha Production
Amemiya S, et al.
Chemical & Pharmaceutical Bulletin, 64(9), 1378-1383 (2016)
A E Håkansson et al.
Bioorganic & medicinal chemistry letters, 11(7), 935-938 (2001-04-11)
Synthesis of a 9-mer alpha-L-LNA (alpha-L-ribo configured locked nucleic acid) containing three 9-(2-O,4-C-methylene-alpha-L-ribofuranosyl)adenine nucleotide monomer(s) has been accomplished. The work involved synthesis of the bicyclic adenine nucleoside via a condensation reaction between L-threo-pentofuranose derivative 1 and 6-N-benzoyladenine followed by C2'-epimerization.
M Kuwahara et al.
Nucleic acids symposium series, 42(42), 31-32 (2000-04-26)
Syntheses of N-Fmoc delta-amino acids with an ether linkage in the main chain and six different nucleobases on the side chain, Fmoc-NH-C*H(CH2-CH2-B)-CH2-O-CH2-COOH (B = N6-benzoyladenine, thymine, uracil, N-benzoylcytosine, guanine, and N2-isobutyrylguanine) are described. The delta-amino acids were prepared through 8-12
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SKUGTIN
B5258-5G04061833045411
B5258-25G04061833045404

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