B0684
Anti-Bad antibody produced in rabbit
affinity isolated antibody, lyophilized powder
Sinónimos:
Anti-BBC2, Anti-BCL2L8
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| Tamaño de envase | SKU | Disponibilidad | Precio |
|---|---|---|---|
| 100 μg | Envío estimado HOYdesdeMILWAUKEE | $642.00 $545.70 |
Acerca de este artículo
Conjugate:
unconjugated
Clone:
polyclonal
Application:
WB
Citations:
4
$545.70
Precio de catálogo$642.00Ahorre 15 %Promoción solo por Internet
Envío estimado HOYDetalles
Está disponible un anticuerpo recombinante y sin conservantes para su diana. Pruebe ZRB1569
Servicio técnico
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Permítanos ayudarlebiological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
lyophilized powder
species reactivity
mouse, human
technique(s)
western blot: 1 μg/mL
UniProt accession no.
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... BAD(572)
mouse ... Bad(12015)
General description
Bad (Bcl-2-antagonist of cell death), initially identified by its interaction with Bcl-2 and Bcl-XL, is a distant Bcl-2 family member. Bad bears only the most universally conserved amino acids within BH1 and BH2 domains, and lacks the typical hydrophobic C-terminal signal anchor.
Immunogen
synthetic peptide corresponding to amino acids 1-21 of human Bad conjugated to KLH.
Application
Anti-Bad antibody produced in rabbit is suitable for western blotting at a concentration of 1μg/mL
Biochem/physiol Actions
The protein encoded by this gene forms heterodimers with BCL-xL and BCL-2 and replaces Bax, which in turn inverts the death repressor activity of Bcl-xL and positively regulates cell apoptosis.Bad is phosphorylated on two serine residues embedded in canonical 14-3-3 binding sites in response to IL-3, a survival factor. Phosphorylated Bad does not bind Bcl-XL and is sequestered in the cytosol bound to 14-3-3, a specific phosphoserine-binding protein. The growth factors that promote cell survival activate the threonine kinase Akt, which phosphorylates Bad causing suppression of apoptosis.
Physical form
lyophilized from a 0.2 μm filtered solution of phosphate buffered saline (PBS) and 5% trehalose
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Este artículo | |||
|---|---|---|---|
| conjugate unconjugated | conjugate unconjugated | conjugate unconjugated | conjugate unconjugated |
| Quality Level 100 | Quality Level - | Quality Level - | Quality Level - |
| biological source rabbit | biological source rabbit | biological source rabbit | biological source rabbit |
| antibody form affinity isolated antibody | antibody form affinity isolated antibody | antibody form affinity isolated antibody | antibody form affinity isolated antibody |
| UniProt accession no. | UniProt accession no. | UniProt accession no. | UniProt accession no. |
| technique(s) western blot: 1 μg/mL | technique(s) immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100, western blot: 1:500-1:1000 | technique(s) ELISA: 1:10000, immunohistochemistry: 1:50-1:100, western blot: 1:500-1:1000 | technique(s) ELISA: 1:20000, immunohistochemistry: 1:50-1:100, western blot: 1:500-1:1000 |
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Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Lishuai Feng et al.
International journal of molecular medicine, 42(2), 1074-1085 (2018-05-12)
Mono‑unsaturated free fatty acids (FFAs) can serve as a predictive indicator of vascular restenosis following interventional therapy, particularly in individuals with high‑fat diet‑induced type 2 diabetes. However, the pathogenic mechanism remains to be fully elucidated. In the present study, the
E Yang et al.
Cell, 80(2), 285-291 (1995-01-27)
To extend the mammalian cell death pathway, we screened for further Bcl-2 interacting proteins. Both yeast two-hybrid screening and lambda expression cloning identified a novel interacting protein, Bad, whose homology to Bcl-2 is limited to the BH1 and BH2 domains.
K Wang et al.
Molecular and cellular biology, 18(10), 6083-6089 (1998-09-19)
The BCL-2 family of proteins is comprised of proapoptotic as well as antiapoptotic members (S. N. Farrow and R. Brown, Curr. Opin. Genet. Dev. 6:45-49, 1996). A prominent death agonist, BAX, forms homodimers and heterodimerizes with multiple antiapoptotic members. Death
Número de artículo de comercio global
| SKU | GTIN |
|---|---|
| B0684-100UG | 04061833380284 |