53886
Tn Antigen
≥99.0% (TLC), powder or crystals
Sinónimos:
GalNac-α-1-O-serine, O-[2-(Acetylamino)-2-deoxy-α-D-galactopyranosyl]-L-serine
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| Tamaño de envase | SKU | Disponibilidad | Precio |
|---|---|---|---|
| 1 mg | Comprobar disponibilidad del carrito | $446.00 |
Acerca de este artículo
Fórmula empírica (notación de Hill):
C11H20N2O8
Número CAS:
Peso molecular:
308.29
UNSPSC Code:
12352204
PubChem Substance ID:
NACRES:
NA.32
MDL number:
$446.00
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Servicio técnico
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Permítanos ayudarleNombre del producto
Tn Antigen, ≥99.0% (TLC)
Quality Level
assay
≥99.0% (TLC)
form
powder or crystals
storage temp.
−20°C
SMILES string
CC(=O)N[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1OC[C@H](N)C(O)=O
InChI
1S/C11H20N2O8/c1-4(15)13-7-9(17)8(16)6(2-14)21-11(7)20-3-5(12)10(18)19/h5-9,11,14,16-17H,2-3,12H2,1H3,(H,13,15)(H,18,19)/t5-,6+,7+,8-,9+,11-/m0/s1
InChI key
REDMNGDGDYFZRE-WKWISIMFSA-N
General description
Tn antigen is a truncated O-glycan, that is commonly noticed in colorectal cancer (CRC). It is usually expressed at high levels in cancer cells. Tn antigen is small in size and simple in structure. It has a non-physiological glycan structure in humans, hence it may be identified as foreign by the immune system.
Biochem/physiol Actions
Tn antigen stimulates colorectal cancer metastasis through the activation of epithelial-mesenchymal transition, mediated by H-Ras. It acts as a precursor to several significant complex O-glycans. Subpopulations of blood cells in all lineages carrying the Tn antigen results in a hematological disorder called Tn syndrome.
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
1 of 1
Este artículo | |||
|---|---|---|---|
| assay ≥99.0% (TLC) | assay ≥95.0% (TLC) | assay - | assay ≥98% (HPLC) |
| Quality Level 100 | Quality Level - | Quality Level 200 | Quality Level 300 |
| form powder or crystals | form powder or crystals | form - | form powder |
| storage temp. −20°C | storage temp. −20°C | storage temp. - | storage temp. 2-8°C |
Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Filip Kveton et al.
Sensors (Basel, Switzerland), 19(24) (2019-12-11)
The study describes development of a glycan biosensor for detection of a tumor-associated antibody. The glycan biosensor is built on an electrochemically activated/oxidized graphene screen-printed electrode (GSPE). Oxygen functionalities were subsequently applied for covalent immobilization of human serum albumin (HSA)
Lenneke A M Cornelissen et al.
Frontiers in oncology, 10, 1622-1622 (2020-10-06)
Expression of the tumor-associated glycan Tn antigen (αGalNAc-Ser/Thr) has been correlated to poor prognosis and metastasis in multiple cancer types. However, the exact mechanisms exerted by Tn antigen to support tumor growth are still lacking. One emerging hallmark of cancer
Tianbo Gao et al.
Biochemical and biophysical research communications, 521(2), 514-520 (2019-11-05)
Aberrant O-glycosylation truncates O-glycans and is known to be closely associated with colorectal cancer (CRC), a major gastrointestinal tumor. CD44 is one of the highly post-transcriptionally modified O-glycoproteins participating in a series of physiological and pathobiological processes. In this research
Número de artículo de comercio global
| SKU | GTIN |
|---|---|
| 53886-1MG | 04061825700052 |