8.55012

Trityl chloride resin

Novabiochem^®

• UNSPSC Code: 12352101

Propiedades

• product line: Novabiochem^®
• form: beads
• reaction suitability: reaction type: Fmoc solid-phase peptide synthesis
• manufacturer/tradename: Novabiochem^®
• application(s): peptide synthesis
• storage temp.: 2-30°C

Descripción

General description

An acid-labile resin for the solid phase immobilization of alcohols ^[1,2,3,4,5], amines ^{[4, 6,7,8,9,10,11,12]}, sugars ^[13], O- and N-linked hydroxylamines ^[14,15], imidazoles ^[16] and carboxylic acids ^[16]. Release of these functionalities is generally achieved using 1-5% TFA in DCM containing 5% TIS. Amines can also be cleaved with 30% HFIP in DCM ^[4]. This resin, although very acid sensitive, can also be used in peptide synthesis ^[17].

Associated Protocols and Technical Articles
Protocols for Loading of Peptide Synthesis Resins

Literature references

[1] C. C. Leznoff (1978) Acc. Chem. Res., 11, 327.
[2] C. Chen, et al. (1994) J. Am. Chem. Soc., 116, 2661.
[3] Z. Li & A. Ganesan (1998) Syn. Lett., 405.
[4] P. Athanassopoulos, et al., Poster 316 presented at the 24thEuropean Peptide Symposium, Edinburgh, 1996.
[5] K. Barlos, et al. (1988) Liebigs Ann. Chem., 1079.
^[6] K. Barlos, et al. in ′Peptides 1992, Proc. 22nd European Peptide Symposium′, C. H. Schneider & A. N. Eberle (Eds), ESCOM, Leiden,1993, pp. 281.
^[7] M. Schuster, et al. (1996) Angew. Chem. Int. Ed. Engl., 35, 1979.
^[8] P. Garibay, et al. (1998) Tetrahedron Lett., 39, 2207.
^[9] Y. Guan, et al. (2000) J. Comb. Chem., 2, 297.
^[10] S. Manku, et al. (2001) J. Org. Chem., 66, 874.
^[11] D. Jönsson, et al. (2001) Tetrahedron Lett., 42, 6953.
^[12] C. A. Olsen, et al. (2003) Org. Lett., 5, 4183.
^[13] F. Peri, et al. (2000) Tetrahedron Lett., 41, 8587.
^[14] U. Bauer, et al. (1997) Tetrahedron Lett., 38, 7233.
^[15] O. Kinzel, et al. (2003) J. Peptide Sci., 9, 375.
^[16] D. P. Matthews, et al. (2000) J Comb. Chem., 2,19.
^[17] K. Barlos, et al. (1989) Tetrahedron Lett., 30, 3943.

Analysis Note

Color (visual): white to yellow to beige
Appearance of substance (visual): beads
Loading (determined from the substitution of the Fmoc-Ala-Leu loaded resin): 1.1 - 1.7 mmol/g
Swelling Volume (in CH₂Cl₂): lot specific result
The polymer matrix is copoly (styrene-1 % DVB), 200 - 400 mesh

Other Notes

Replaces: 01-64-0074

Legal Information

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Clase de almacenamiento: 11 - Combustible Solids
• wgk: WGK 1
• flash_point_c: Not applicable