676491

VEGF Inducer, GS4012

A cell-permeable pyridinyl-thioether compound that acts as a potent inducer of VEGF and VEGF-mediated vessel formation.

• Sinónimos: VEGF Inducer, GS4012, 4-(2-(4-Methoxyphenylsulfanyl)ethyl)pyridine, HCl, GS4012
• Fórmula empírica (notación de Hill): C₁₄H₁₅NOS · xHCl
• Número CAS: 328073-92-3
• Peso molecular: 245.34 (free base basis)
• MDL number: MFCD00550210
• UNSPSC Code: 12352200
• NACRES: NA.51
• Assay: ≥95% (HPLC)
• Form: solid
• Storage condition: OK to freeze, desiccated (hygroscopic), protect from light

Propiedades

• Quality Segment: 100
• assay: ≥95% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, desiccated (hygroscopic), protect from light
• color: white
• solubility: DMSO: 200 mg/mL, methanol: 50 mg/mL, water: soluble
• shipped in: ambient
• storage temp.: 2-8°C
• SMILES string: S(CCc2ccncc2)c1ccc(cc1)OC.Cl
• InChI: 1S/C14H15NOS.ClH/c1-16-13-2-4-14(5-3-13)17-11-8-12-6-9-15-10-7-12;/h2-7,9-10H,8,11H2,1H3;1H
• InChI key: CYZALCLQLHDAEC-UHFFFAOYSA-N

Descripción

General description

A cell-permeable and potent inducer of VEGF and VEGF-mediated blood vessel formation. GS4012-induced upregulation of VEGF correlates with its ability to suppress the gridlock/coarctation phenotype (7.5 µg/ml) in Zebrafish and to stimulate tubule network formation (5 µg/ml) in HUVECs. An essential molecule required during angioblasts cell fate determination.

A cell-permeable pyridinyl-thioether compound that acts as a potent inducer of VEGF and VEGF-mediated vessel formation. GS4012-induced upregulation of VEGF correlates well with its ability to suppress the gridlock/coarctation phenotype (7.5 µg/ml) in Zebrafish and to stimulate tubule network formation (5 µg/ml) in HUVECs.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
Potent inducer of VEGF and VEGF-mediated vessel formation

Product does not compete with ATP.

Reversible: no

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Peterson, R.T., et al. 2004. Nat. Biotechnol.22, 595.
Depre, C., et al. 2003. Circulation108, 2723.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Información de seguridad

• Clase de almacenamiento: 11 - Combustible Solids
• wgk: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable