Following reconstitution in DMSO, it is recommended to aliquot and freeze stock solutions at -20°C for up to 1 month. The solution stability at -80°C has not been determined for this product.
203391
(−)-Blebbistatin
≥98% (HPLC), solid, ATPase inhibitor, Calbiochem®
Sinónimos:
(-)-Blebbistatin
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| Tamaño de envase | SKU | Disponibilidad | Precio |
|---|---|---|---|
| 1 mg | Comprobar disponibilidad del carrito | $238.00 |
Acerca de este artículo
Fórmula empírica (notación de Hill):
C18H16N2O2
Número CAS:
Peso molecular:
292.33
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
solid
Quality level:
Storage condition:
OK to freeze, protect from light
$238.00
Comprobar disponibilidad del carrito
Servicio técnico
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Permítanos ayudarleNombre del producto
(-)-Blebbistatin, The active enantiomer of (±)-Blebbistatin that accounts for the inhibitory activity towards ATPase and myosin II-dependent cellular processes.
Quality Level
assay
≥98% (HPLC)
form
solid
potency
2 μM IC50
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
yellow
solubility
methanol: 1.5 mg/mL, 100% DMSO: 100 mg/mL, 90% DMSO: 75 mg/mL
shipped in
wet ice
storage temp.
−20°C
SMILES string
N2(CC[C@@]3(C2=Nc4c(cc(cc4)C)C3=O)O)c1ccccc1
InChI
1S/C18H16N2O2/c1-12-7-8-15-14(11-12)16(21)18(22)9-10-20(17(18)19-15)13-5-3-2-4-6-13/h2-8,11,22H,9-10H2,1H3/t18-/m1/s1
InChI key
LZAXPYOBKSJSEX-GOSISDBHSA-N
General description
The active enantiomer of (±)-Blebbistatin (Cat. No. 203390) that accounts for the inhibitory activity towards ATPase (IC50 = ~2 µM) and myosin II-dependent cellular processes. Also reported to potently inhibit the actomyosin ATPase activities of expressed smooth muscle myosin IIA (SMA) and smooth muscle myosin IIB (SMB) smooth muscle myosin II heavy-chain isoforms (IC50 ~3 µM).
Biochem/physiol Actions
Product does not compete with ATP.
Reversible: yes
Cell permeable: yes
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month in 90% DMSO or methanol (-20°C). Stock solutions in 100% DMSO are unstable; reconstitute just prior to use.
Other Notes
Eddinger, T.J. et al. 2007. J. Pharmacol. Exp. Ther.320, 865.
Shu, S., et al. 2005. Proc. Natl. Acad. Sci. USA102, 1472.
Kovacs, M., et al. 2004. J. Biol. Chem.279, 35557.
Straight, A.F., et al. 2003. Science299, 1743.
Shu, S., et al. 2005. Proc. Natl. Acad. Sci. USA102, 1472.
Kovacs, M., et al. 2004. J. Biol. Chem.279, 35557.
Straight, A.F., et al. 2003. Science299, 1743.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Harmful & Carcinogenic / Teratogenic (E)
Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 3
Certificados de análisis (COA)
Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»
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Número de artículo de comercio global
| SKU | GTIN |
|---|---|
| 203391-1MG | 04055977221275 |
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Can this be stored in -80 once in 90%DMSO?
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