P0103
Prodigiosin hydrochloride
from Serratia marcescens, ≥98% (HPLC), powder
Sinónimos:
2,2′-Bi-1H-Pyrrole,4-methoxy-5-[(5-methyl-4-pentyl-2H-pyrrol-2-ylidene)methyl, 2-Methyl-3-amyl-6-methoxyprodigiosene
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| Tamaño de envase | SKU | Disponibilidad | Precio |
|---|---|---|---|
| 100 μg | Comprobar disponibilidad del carrito | US$ 583,00 |
Acerca de este artículo
Fórmula empírica (notación de Hill):
C20H25N3O · HCl
Número CAS:
Peso molecular:
359.89
NACRES:
NA.32
UNSPSC Code:
12352200
US$ 583,00
PRECIOS SIN IMPUESTOS NACIONALES
Comprobar disponibilidad del carrito
Servicio técnico
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Permítanos ayudarlebiological source
Serratia marcescens
Quality Level
assay
≥98% (HPLC)
form
powder
solubility
DMSO: soluble, H2O: insoluble, acetonitrile: soluble, chloroform: soluble, methanol: soluble
shipped in
wet ice
storage temp.
−20°C
General description
Prodigiosin is a red pigment with common pyrrolyl pyrromethene skeleton and is biosynthesized by Serratia marcescens and other bacteria.
Biochem/physiol Actions
Prodigiosin (PG) exhibits antibacterial, anticancer, cytotoxic, immunosuppressive and antiproliferative activities. Prodigiosin stimulates apoptosis in hematopoietic cancer cells and in cells derived from other human cancers, such as gastric and colon, with no marked toxicity in nonmalignant cell lines.[1] In addition, prodigiosin also has p53-independent anti-proliferative activity. Experimental studies show that prodigiosin promotes various cellular processes such as cell shrinkage, chromatin condensation, restructuring of actin microfilament network and detachment of cells from the cell culture substrate. Different targets and mechanisms of action were described for prodigiosin, including induction of single- and double stranded DNA breaks modulation of pH, regulation of mitogen-activated protein kinase, and inhibition of cell cycle progression.
Prodigiosin, a tripyrrole red pigment biosynthesized by Serratia marcescens and other bacteria, induces apoptosis and exhibits antibacterial, anticancer, cytotoxic, immunosuppressive, and antiproliferative activities.
Prodigiosin, a tripyrrole red pigment biosynthesized by Serratia marcescens and other bacteria, exhibits antibacterial, anticancer, cytotoxic, immunosuppressive, and antiproliferative activities. Prodigiosin induces apoptosis in hematopoietic cancer cells and cells derived from other human cancers, including gastric and colon with no marked toxicity in nonmalignant cell lines. Morphological analysis of prodigiosin-treated cells demonstrated that prodigiosin induces cell shrinkage, chromatin condensation, reorganization of actin microfilament architecture, and detachment of cells from the cell culture substrate. Different targets and mechanisms of action are described for prodigiosin, including induction of single- and double-strand DNA breaks, modulation of pH, regulation of mitogen-activated protein kinase, and inhibition of cell cycle progression.
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Este artículo | |||
|---|---|---|---|
| assay ≥98% (HPLC) | assay ≥95% (HPLC) | assay ≥95% (HPLC) | assay ≥98% (HPLC) |
| biological source Serratia marcescens | biological source Streptomyces parvulus | biological source - | biological source - |
| Quality Level 200 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| form powder | form powder | form solid | form powder |
| shipped in wet ice | shipped in - | shipped in ambient | shipped in - |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. −20°C |
Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Contenido relacionado
Instructions
The prodigiosins, proapoptotic drugs with anticancer properties.
Perez-Tomas R
Biochemical Pharmacology, 66(8), 1447-1452 (2003)
Prodigiosin induces cell death and morphological changes indicative of apoptosis in gastric cancer cell line HGT-1.
Histology and Histopathology, 16(2), 415-421 (2001)
Jacob M C Shaffer et al.
Frontiers in microbiology, 14, 1156033-1156033 (2023-05-30)
The McMurdo Dry Valleys of Antarctica experience a range of selective pressures, including extreme seasonal variation in temperature, water and nutrient availability, and UV radiation. Microbial mats in this ecosystem harbor dense concentrations of biomass in an otherwise desolate environment.
Número de artículo de comercio global
| SKU | GTIN |
|---|---|
| P0103-100UG | 04061834290810 |