G014
S(−)-Baclofen hydrochloride
≥98% (HPLC), solid
Sinónimos:
S(–)-β-(Aminomethyl)-4-chlorobenzenepropanoic acid hydrochloride
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Acerca de este artículo
Fórmula empírica (notación de Hill):
C10H12ClNO2 · HCl
Número CAS:
Peso molecular:
250.12
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
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Servicio técnico
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Permítanos ayudarleQuality Level
assay
≥98% (HPLC)
form
solid
optical activity
[α]28/D −2.2°, c = 0.9 in methanol(lit.)
color
white
solubility
DMSO: >20 mg/mL
SMILES string
Cl[H].NC[C@@H](CC(O)=O)c1ccc(Cl)cc1
InChI
1S/C10H12ClNO2.ClH/c11-9-3-1-7(2-4-9)8(6-12)5-10(13)14;/h1-4,8H,5-6,12H2,(H,13,14);1H/t8-;/m1./s1
InChI key
WMNUVYYLMCMHLU-DDWIOCJRSA-N
Biochem/physiol Actions
S(−)-Baclofen hydrochloride is a less active enantiomer of baclofen.
Other Notes
Same enantiomer as S(+)-baclofen free base.
Clase de almacenamiento
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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R Paredes et al.
Psychopharmacology, 97(3), 358-364 (1989-01-01)
The behavior effects of racemic baclofen and the R and S enantiomers were studied in order to determine whether the stereospecificity found in receptor binding studies also applies to the behavioral actions of the drug. Racemic and R-baclofen inhibited sexual
E Falch et al.
Journal of neurochemistry, 47(3), 898-903 (1986-09-01)
The affinities of a number of analogues of gamma-aminobutyric acid (GABA) for GABAA and GABAB receptor sites and GABA uptake were studied using rat brain membrane preparations. Studies on the (S)-(+)- and (R)-(-)-isomers of baclofen, 3-hydroxy-4-aminobutyric acid (3-OH-GABA), and 4,5-dihydromuscimol
B Witczuk et al.
Polish journal of pharmacology and pharmacy, 32(2), 187-196 (1980-03-01)
Racemic 3-(p-chlorophenyl)-4-aminobutanoic acid was resolved into enantiomers and their absolute configuration determined. Pharmacological activity of hydrochlorides of the racemic acid and its enantiomers has been determined. The R(+) enantiomer was found to be 4.2-9.2-fold as effective as the S(-) one
Número de artículo de comercio global
| SKU | GTIN |
|---|---|
| G014-25MG | 04061833623237 |
| G014-500MG | 04061833007150 |
| G014-100MG | 04061833007136 |