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E9658

Enalaprilat dihydrate

≥98% (HPLC)

Sinónimos:

(2S)-1-[(2S)-2-[[(1S)-1-Carboxy-3-phenyl-propyl]amino]propanoyl]pyrrolidine-2-carboxylic acid, Vasotec

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Tamaño de envaseSKUDisponibilidadPrecio
5 mg
Comprobar disponibilidad del carrito
US$ 175,00
25 mg
Comprobar disponibilidad del carrito
US$ 669,00

Acerca de este artículo

Fórmula empírica (notación de Hill):
C18H24N2O5 ·2H2O
Número CAS:
84680-54-6
Peso molecular:
384.42
NACRES:
NA.77
PubChem Substance ID:
329799089
UNSPSC Code:
12352200
EC Number:
278-459-3
MDL number:
MFCD00941393
Assay:
≥98% (HPLC)
Quality level:
100

US$ 175,00

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Quality Level

100

assay

≥98% (HPLC)

solubility

H2O: 14 mg/mL at 60 °C (warming for 5 minutes), DMSO: 64 mg/mL

originator

Merck & Co., Inc., Kenilworth, NJ, U.S.

storage temp.

room temp

SMILES string

O.O.C[C@H](N[C@@H](CCc1ccccc1)C(O)=O)C(=O)N2CCC[C@H]2C(O)=O

InChI

1S/C18H24N2O5.2H2O/c1-12(16(21)20-11-5-8-15(20)18(24)25)19-14(17(22)23)10-9-13-6-3-2-4-7-13;;/h2-4,6-7,12,14-15,19H,5,8-11H2,1H3,(H,22,23)(H,24,25);2*1H2/t12-,14-,15-;;/m0../s1

InChI key

MZYVOFLIPYDBGD-MLZQUWKJSA-N

Gene Information

human ... ACE(1636)

Biochem/physiol Actions

Enalaprilat is an inhibitor of angiotensin converting enzyme (ACE), antihypertensive, and a Bradykinin B1 receptor activator.
Enalaprilat is an inhibitor of angiotensin converting enzyme (ACE), antihypertensive, and a Bradykinin B1 receptor activator. Enalaprilat has nM potency versus ACE and also activates B1 receptors to release NO.
Enalapril, the ethyl ester of enalaprilat exhibits slight pharmacological activity until it is hydrolyzed in the liver to enalaprilat. Enalaprilat, a IV form of an angiotensin-converting-enzyme inhibitor (ACE) prevents the transformation of angiotensin I to angiotensin II, a potent vasoconstrictor.

Features and Benefits

This compound is featured on the Angiotensin Receptors and Bradykinin Receptors pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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1 of 1

Este artículo
R0404T4827Y0000615
Enalaprilat dihydrate ≥98% (HPLC)

Sigma-Aldrich

E9658

Enalaprilat dihydrate

Ramipril ≥98% (HPLC)

Sigma-Aldrich

R0404

Ramipril

Trandolapril ≥98% (HPLC), white, powder

Sigma-Aldrich

T4827

Trandolapril

Enalaprilat dihydrate European Pharmacopoeia (EP) Reference Standard

Y0000615

Enalaprilat dihydrate

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

-

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

-

storage temp.

room temp

storage temp.

2-8°C

storage temp.

-

storage temp.

2-8°C

solubility

H2O: 14 mg/mL at 60 °C (warming for 5 minutes), DMSO: 64 mg/mL

solubility

DMSO: ~18 mg/mL

solubility

DMSO: ≥20 mg/mL

solubility

-

Gene Information

human ... ACE(1636)

Gene Information

human ... ACE(1636)

Gene Information

human ... ACE(1636)

Gene Information

human ... ACE(1636)

originator

Merck & Co., Inc., Kenilworth, NJ, U.S.

originator

Sanofi Aventis

originator

Abbott

originator

-

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Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificados de análisis (COA)

Lot/Batch Number
0000507893
0000507893
0000352784
0000352784
0000205055

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Artículos

Angiotensin Receptors

We offer many products related to angiotensin receptors for your research needs.

Gérémy Abdull Koumbadinga et al.
Peptides, 31(8), 1546-1554 (2010-05-11)
Angiotensin converting enzyme (ACE) is a drug target and an effective bradykinin (BK)-inactivating ectopeptidase. We exploited a recently described [(3)H]enalaprilat binding assay to quantify the full dynamic range of ACE expression in intact human umbilical vein endothelial cells (HUVECs) stimulated
P F O'Tierney et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 299(2), R573-R578 (2010-05-21)
The fetal heart is highly sensitive to changes in mechanical load. We have previously demonstrated that increased cardiac load can stimulate cell cycle activity and maturation of immature cardiomyocytes, but the effects of reduced load are not known. Sixteen fetal
Diamantino Ribeiro Salgado et al.
Shock (Augusta, Ga.), 35(6), 542-549 (2011-02-02)
Severe sepsis is frequently associated with microcirculatory abnormalities despite seemingly adequate hemodynamic resuscitation. As increased serum angiotensin II levels may play a role in this dysfunction, we evaluated the microcirculatory effects of enalaprilat in an experimental model of septic shock.
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Número de artículo de comercio global

SKUGTIN
E9658-25MG04061833609149
E9658-5MG04061833609156

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