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A3281

N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide hydrochloride

Sinónimos:

W-7

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Tamaño de envaseSKUDisponibilidadPrecio
25 mg
Comprobar disponibilidad del carrito
US$ 203,00
100 mg
Comprobar disponibilidad del carrito
US$ 525,00

Acerca de este artículo

Fórmula empírica (notación de Hill):
C16H21ClN2O2S · HCl
Número CAS:
61714-27-0
Peso molecular:
377.33
UNSPSC Code:
12352200
NACRES:
NA.77
PubChem Substance ID:
24278067
MDL number:
MFCD00012559
Beilstein/REAXYS Number:
6030174
Form:
powder
Quality level:
200

US$ 203,00

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form

powder

Quality Level

200

mode of action

cell membrane | interferes, enzyme | inhibits

storage temp.

−20°C

SMILES string

Cl[H].NCCCCCCNS(=O)(=O)c1cccc2c(Cl)cccc12

InChI

1S/C16H21ClN2O2S.ClH/c17-15-9-5-8-14-13(15)7-6-10-16(14)22(20,21)19-12-4-2-1-3-11-18;/h5-10,19H,1-4,11-12,18H2;1H

InChI key

OMMOSRLIFSCDBL-UHFFFAOYSA-N

Gene Information

human ... CAMK2A(815), CAMK2B(816)

Application

N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide hydrochloride has been used to study its effect of on coated pit staining.[1]

Biochem/physiol Actions

N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7) is a calmodulin antagonist. It can prevent calcium-dependent protein kinase, that is sensitive to phospholipid.

Features and Benefits

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

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Este artículo
SML0657681629GF37370752
N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide hydrochloride

Sigma-Aldrich

A3281

N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide hydrochloride

N-(6-Aminohexyl)-1-naphthalenesulfonamide hydrochloride ≥98% (HPLC)

Sigma-Aldrich

SML0657

N-(6-Aminohexyl)-1-naphthalenesulfonamide hydrochloride

W-7, Hydrochloride A cell-permeable and reversible calmodulin antagonist that inhibits myosin light chain kinase (IC50 = 51 µM) and Ca2+-calmodulin-dependent phosphodiesterase (IC50 = 28 µM).

Sigma-Aldrich

681629

W-7, Hydrochloride

Tungsten powder, max. particle size 25 micron, weight 1000 g, purity 99.9%

GF37370752

Tungsten

form

powder

form

powder or crystals

form

crystalline solid

form

powder

Quality Level

200

Quality Level

100

Quality Level

100

Quality Level

-

storage temp.

−20°C

storage temp.

room temp

storage temp.

2-8°C

storage temp.

-

mode of action

cell membrane | interferes, enzyme | inhibits

mode of action

-

mode of action

-

mode of action

-

Gene Information

human ... CAMK2A(815), CAMK2B(816)

Gene Information

-

Gene Information

-

Gene Information

-

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificados de análisis (COA)

Lot/Batch Number
0000273170
0000273170
SLBR5186V
SLBM7616V
SLBC0044V

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Artículos

Discover Bioactive Molecules for Nucleotides

Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.

M Osawa et al.
FEBS letters, 442(2-3), 173-177 (1999-02-03)
Small-angle X-ray scattering and nuclear magnetic resonance were used to investigate the structural change of calcium-bound calmodulin (Ca2+/CaM) in solution upon binding to its antagonist, N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7). The radius of gyration was 17.4+/-0.3 A for Ca2+/CaM-W-7 with a molar ratio
L H Wang et al.
The Journal of cell biology, 123(5), 1107-1117 (1993-12-01)
The clathrin-coated pit lattice is held onto the plasma membrane by an integral membrane protein that binds the clathrin AP-2 subunit with high affinity. In vitro studies have suggested that this protein controls the assembly of the pit because membrane
Valentin Jaumouillé et al.
Channels (Austin, Tex.), 5(4), 308-313 (2011-06-10)
NHE3 is regulated via alterations in membrane surface charge. This is achieved through altered binding of cationic regions in the cytosolic-terminus of the exchanger with the inner leaflet of the plasma membrane. Calmodulin antagonists, including W-7, regulate surface potential and
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SKUGTIN
A3281-100MG04061833267387
A3281-25MG04061833360606
A3281-250MG04061833267394

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