EI3
Antipain
Inhibitor of papain, trypsin and plasmin
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UNSPSC Code:
51111800
NACRES:
NA.77
eCl@ss:
32160405
Quality level:
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| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level - |
| manufacturer/tradename Chemicon® | manufacturer/tradename Calbiochem® | manufacturer/tradename Calbiochem® | manufacturer/tradename Roche |
| shipped in dry ice | shipped in ambient | shipped in ambient | shipped in - |
General description
Antipain is known for regulating the number of chromosomal aberrations caused by the S-phase-dependent alkylating agent N-methyl-N′-nitro-N-nitrosoguanidine. It can also diminish the nuclear binding of the estrogen-receptor complex in MCF-7 breast tumor cells.
Application
Antipain has been used in microfluidic chip assay.
Biochem/physiol Actions
Inhibitor Type: Protease Inhibitors
Physical form
Lyophilized no preservatives.
Properties: Soluble in H2O, methanol and DMSO (Stock solution: 10 mM). Stable at -20° C.
Mechanism of action: Formation of a hemicetal adduct between the aldehyde group of the inhibitor and the active serine of the proteinase.
Inhibition spectrum: Inhibits papain, trypsin and plasmin to a lesser extent. More specific for papain and trypsin than leupeptin. The inhibitory potency of antipain is 100-fold higher than that of elastatinal.
Pale yellow powder; material is isolated from cultured media of microorganisms. As with many of these compounds, they are too inherently unstable to allow for high standards of purity. The homogeneity of these compounds cannot be guaranteed except for their specific inhibitory activities.
Properties: Soluble in H2O, methanol and DMSO (Stock solution: 10 mM). Stable at -20° C.
Mechanism of action: Formation of a hemicetal adduct between the aldehyde group of the inhibitor and the active serine of the proteinase.
Inhibition spectrum: Inhibits papain, trypsin and plasmin to a lesser extent. More specific for papain and trypsin than leupeptin. The inhibitory potency of antipain is 100-fold higher than that of elastatinal.
Pale yellow powder; material is isolated from cultured media of microorganisms. As with many of these compounds, they are too inherently unstable to allow for high standards of purity. The homogeneity of these compounds cannot be guaranteed except for their specific inhibitory activities.
Preparation Note
Maintain dry at -20ºC for up to 18 months. Store reconstituted product in aliquots at -20ºC for up to 9 months. Do not thaw and refreeze.
Analysis Note
pH 1% aqueous solution: 5.2
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificados de análisis (COA)
Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»
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Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.
Protease inhibitor antipain reduces nuclear binding of estrogen-receptor complex in MCF-7 breast tumor cells
Umans RS, et al.
Carcinogenesis, 5(10), 1355-1357 (1984)
Structure of antipain, a new Sakaguchi-positive product of streptomyces.
S Umezawa et al.
The Journal of antibiotics, 25(4), 267-270 (1972-04-01)
Tumor-associated macrophage-derived exosomal miR21-5p promotes tumor angiogenesis by regulating YAP1/HIF-1alpha axis in head and neck squamous cell carcinoma
Yan Q, et al.
Cellular and Molecular Life Sciences, 81(1), 1-23 (2024)
Antipain-mediated suppression of X-ray-induced chromosomal aberrations in human lymphocytes
Afzal, et al.
Carcinogenesis, 10(7), 1193-1196 (1989)
Contenido relacionado
Número de artículo de comercio global
| SKU | GTIN |
|---|---|
| EI3 | 04053252508844 |
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