This antibody is supplied in the form of unpurified polyclonal rabbit serum, for which the exact specific antibody concentration is not determined. However, for polyclonal antiserum, the specific antibody concentrations could range from 1-10 mg/mL serum, but typically range from 1–3 mg/mL serum.
AB2201
Anti-mPER1 (residues 6-21) Antibody
serum, from rabbit
Sinónimos:
Circadian clock protein PERIOD 1, Circadian pacemaker protein Rigui, Period, drosophila, homolog of period 1, period (Drosophila) homolog 1, period homolog 1 (Drosophila)
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UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
polyclonal
Application:
WB
Citations:
18
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Servicio técnico
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Permítanos ayudarlebiological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
serum
antibody product type
primary antibodies
clone
polyclonal
species reactivity
human, mouse, rat
technique(s)
western blot: suitable
GenBank accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
mouse ... Per1(18626)
General description
136 kDa
This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. Circadian expression in the suprachiasmatic nucleus continues in constant darkness, and a shift in the light/dark cycle evokes a proportional shift of gene expression in the suprachiasmatic nucleus. The specific function of this gene is not yet known. Alternative splicing has been observed in this gene; however, these variants have not been fully described.
Application
Detect mPER1 (residues 6-21) using this Anti-mPER1 (residues 6-21) Antibody validated for use in WB.
Immunohistichemistry:
Tested on whole brain (SCN; peak staining at CT/ZT12). Optimium working dilutions need to be determined by end used.
Tested on whole brain (SCN; peak staining at CT/ZT12). Optimium working dilutions need to be determined by end used.
Biochem/physiol Actions
Cat. # AB2201 will recognize the N-terminus of mPER1.
May react with Drosophila, Arvicanthis niloticus and Mesocricetus auratus based on sequence homology. Reactivity with other species has not been tested.
Analysis Note
Routinely tested by western blot on human brain lysate
Legal Information
GenBank is a registered trademark of United States Department of Health and Human Services
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Este artículo | |||
|---|---|---|---|
| conjugate unconjugated | conjugate unconjugated | conjugate unconjugated | conjugate unconjugated |
| biological source rabbit | biological source rabbit | biological source guinea pig | biological source rabbit |
| antibody form serum | antibody form serum | antibody form affinity isolated antibody | antibody form affinity isolated antibody |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| shipped in wet ice | shipped in wet ice | shipped in - | shipped in wet ice |
| technique(s) western blot: suitable | technique(s) western blot: suitable | technique(s) ChIP: suitable (ChIP-seq), immunocytochemistry: suitable | technique(s) immunocytochemistry: suitable, immunohistochemistry: suitable, western blot: suitable |
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Clase de almacenamiento
10 - Combustible liquids
wgk
WGK 1
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Circadian key component CLOCK/BMAL1 interferes with segmentation clock in mouse embryonic organoids.
Yasuhiro Umemura et al.
Proceedings of the National Academy of Sciences of the United States of America, 119(1) (2021-12-22)
In mammals, circadian clocks are strictly suppressed during early embryonic stages, as well as in pluripotent stem cells, by the lack of CLOCK/BMAL1-mediated circadian feedback loops. During ontogenesis, the innate circadian clocks emerge gradually at a late developmental stage, and
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Circadian regulation of gene expression is prevalent and plays critical roles in cell differentiation. However, its roles in the reprogramming of differentiated cells remain largely unknown. Here, we found that one of the master circadian regulators PER1 promoted virus-mediated reprogramming
Número de artículo de comercio global
| SKU | GTIN |
|---|---|
| AB2201 | 04053252362163 |
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