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09-409

Anti-SUMO-1 Antibody

Name: Anti-SUMO-1 Antibody
Brand: MM

Upstate^®, from rabbit

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UNSPSC Code:

12352203

NACRES:

NA.41

eCl@ss:

32160702

Conjugate:

unconjugated

Clone:

polyclonal

Application:

Citations:

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Propiedades

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

purified antibody

antibody product type

primary antibodies

clone

polyclonal

species reactivity (predicted by homology)

all

manufacturer/tradename

Upstate^®

technique(s)

western blot: suitable

isotype

IgG

NCBI accession no.

NM_001005781.1, NM_001005782.1, NM_003352.4

UniProt accession no.

P63165

shipped in

dry ice

target post-translational modification

unmodified

Gene Information

human ... SENP2(59343), SUMO1(7341)

Descripción

General description

The small ubiquitin-related modifier SUMO-1 belongs to the growing family of ubiquitin-related proteins involved in post translational protein modification1. It is present in all eukaryotic kingdoms and is highly conserved from yeast to humans. SUMO-1 does not appear to target proteins for degradation but seems to be involved in the modulation of protein-protein interactions. An increasing number of SUMO-1 substrates are being described but three major substrates for SUMO-1 modification are RanGAP1 and PML proteins.

Immunogen

Synthetic peptide corresponding to amino acid residues 11-101 of human SUMO-1.

Application

Anti-SUMO-1 Antibody detects level of SUMO-1 & has been published & validated for use in WB.

Biochem/physiol Actions

Recognizes SUMO-1. This antibody shows no cross-reactivity with ubiquitin, multi-ubiquitin chains, SUMO2/3, UCRP, Nedd8, and FAT10.

Physical form

100 µL of purified by salt precipitation in PBS containing 0.01% sodium azide. Dilute to working strength with 50mM Tris-HCl buffer (pH 7.6) containing 1.5% sodium chloride and 1% normal goat serum (if a goat anti-rabbit IgG linker antibody is to be used).

Format: Purified

Other Notes

Replaces: 04-453

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

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Este artículo	07-2167	MABS2039	MABS2071
Sigma-Aldrich 09-409 Anti-SUMO-1 Antibody	Sigma-Aldrich 07-2167 Anti-SUMO 2/3 Antibody	Sigma-Aldrich MABS2039 Anti-SUMO-2/3 Antibody, clone 8A2	Sigma-Aldrich MABS2071 Anti-SUMO-1 Antibody, clone 21C7
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
antibody form purified antibody	antibody form -	antibody form purified immunoglobulin	antibody form purified immunoglobulin
clone polyclonal	clone polyclonal	clone 8A2, monoclonal	clone 21C7, monoclonal
biological source rabbit	biological source rabbit	biological source mouse	biological source mouse
technique(s) western blot: suitable	technique(s) immunoprecipitation (IP): suitable, western blot: suitable	technique(s) immunocytochemistry: suitable, immunoprecipitation (IP): suitable, western blot: suitable	technique(s) immunocytochemistry: suitable, immunofluorescence: suitable, immunohistochemistry: suitable, immunoprecipitation (IP): suitable, western blot: suitable
Gene Information human ... SENP2(59343), SUMO1(7341)	Gene Information human ... SUMO2(6613) mouse ... Sumo2(170930) opossum ... Sumo2(123244757) rat ... Sumo2(690244)	Gene Information human ... SUMO2(6613)	Gene Information human ... SUMO1(7341)

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wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Clase de almacenamiento

12 - Non Combustible Liquids

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Structure determination of the small ubiquitin-related modifier SUMO-1.

P Bayer et al.

Journal of molecular biology, 280(2), 275-286 (1998-07-09)

The recently discovered small ubiquitin-related modifier SUMO-1 belongs to the growing family of ubiquitin-related proteins involved in postranslational protein modification. Unlike ubiquitin, SUMO-1 does not appear to target proteins for degradation but seems to be involved in the modulation of

SUMO/sentrin: protein modifiers regulating important cellular functions.

C Kretz-Remy et al.

Biochemistry and cell biology = Biochimie et biologie cellulaire, 77(4), 299-309 (1999-11-05)

Regulation of protein functions can be achieved by posttranslational protein modifications. One of the most studied modifications has been conjugation to ubiquitin, which mainly targets substrate proteins for degradation by the 26 S proteasome. Recently, SUMO/sentrin, a ubiquitin-like protein has

The insulin/IGF signaling cascade modulates SUMOylation to regulate aging and proteostasis in Caenorhabditis elegans.

Lorna Moll et al.

eLife, 7 (2018-11-08)

Although aging-regulating pathways were discovered a few decades ago, it is not entirely clear how their activities are orchestrated, to govern lifespan and proteostasis at the organismal level. Here, we utilized the nematode Caenorhabditis elegans to examine whether the alteration

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SKU	GTIN
09-409	04053252337758

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